The Expression of Twist in Differentiated Thyroid Carcinomas

Differentiated thyroid carcinoma are lesions with a generally favorable prognosis, although there are patients with risk of recurrence and metastasis. In this study we analyzed 43 thyroid carcinomas referring to Twist expression in relation to clinicopathological parameters. The immunoreaction was i...

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Detalles Bibliográficos
Autores principales: CALANGIU, CRISTINA MARIANA, MĂRGĂRITESCU, C., CERNEA, DANIELA, STEPAN, A., SIMIONESCU, CRISTIANA EUGENIA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340438/
https://www.ncbi.nlm.nih.gov/pubmed/25729603
http://dx.doi.org/10.12865/CHSJ.40.03.05
Descripción
Sumario:Differentiated thyroid carcinoma are lesions with a generally favorable prognosis, although there are patients with risk of recurrence and metastasis. In this study we analyzed 43 thyroid carcinomas referring to Twist expression in relation to clinicopathological parameters. The immunoreaction was identified in 79% of cases, the expression of twist being low or high, with no differences in relation to the tumors type or subtype. Twist immunoexpression differ depending on tumor stage and presence of metastases, the immunostain being significantly higher in invasive tumors to adjacent structures and in cases of tumors with metastasized. In differentiated thyroid carcinomas overexpression of Twist is associated with an invasive and metastatic immunophenotype.

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