The Expression of Twist in Differentiated Thyroid Carcinomas

Differentiated thyroid carcinoma are lesions with a generally favorable prognosis, although there are patients with risk of recurrence and metastasis. In this study we analyzed 43 thyroid carcinomas referring to Twist expression in relation to clinicopathological parameters. The immunoreaction was i...

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Autores principales: CALANGIU, CRISTINA MARIANA, MĂRGĂRITESCU, C., CERNEA, DANIELA, STEPAN, A., SIMIONESCU, CRISTIANA EUGENIA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340438/
https://www.ncbi.nlm.nih.gov/pubmed/25729603
http://dx.doi.org/10.12865/CHSJ.40.03.05
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author CALANGIU, CRISTINA MARIANA
MĂRGĂRITESCU, C.
CERNEA, DANIELA
STEPAN, A.
SIMIONESCU, CRISTIANA EUGENIA
author_facet CALANGIU, CRISTINA MARIANA
MĂRGĂRITESCU, C.
CERNEA, DANIELA
STEPAN, A.
SIMIONESCU, CRISTIANA EUGENIA
author_sort CALANGIU, CRISTINA MARIANA
collection PubMed
description Differentiated thyroid carcinoma are lesions with a generally favorable prognosis, although there are patients with risk of recurrence and metastasis. In this study we analyzed 43 thyroid carcinomas referring to Twist expression in relation to clinicopathological parameters. The immunoreaction was identified in 79% of cases, the expression of twist being low or high, with no differences in relation to the tumors type or subtype. Twist immunoexpression differ depending on tumor stage and presence of metastases, the immunostain being significantly higher in invasive tumors to adjacent structures and in cases of tumors with metastasized. In differentiated thyroid carcinomas overexpression of Twist is associated with an invasive and metastatic immunophenotype.
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spelling pubmed-43404382015-02-27 The Expression of Twist in Differentiated Thyroid Carcinomas CALANGIU, CRISTINA MARIANA MĂRGĂRITESCU, C. CERNEA, DANIELA STEPAN, A. SIMIONESCU, CRISTIANA EUGENIA Curr Health Sci J Original Paper Differentiated thyroid carcinoma are lesions with a generally favorable prognosis, although there are patients with risk of recurrence and metastasis. In this study we analyzed 43 thyroid carcinomas referring to Twist expression in relation to clinicopathological parameters. The immunoreaction was identified in 79% of cases, the expression of twist being low or high, with no differences in relation to the tumors type or subtype. Twist immunoexpression differ depending on tumor stage and presence of metastases, the immunostain being significantly higher in invasive tumors to adjacent structures and in cases of tumors with metastasized. In differentiated thyroid carcinomas overexpression of Twist is associated with an invasive and metastatic immunophenotype. Medical University Publishing House Craiova 2014 2014-08-04 /pmc/articles/PMC4340438/ /pubmed/25729603 http://dx.doi.org/10.12865/CHSJ.40.03.05 Text en Copyright © 2014, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
CALANGIU, CRISTINA MARIANA
MĂRGĂRITESCU, C.
CERNEA, DANIELA
STEPAN, A.
SIMIONESCU, CRISTIANA EUGENIA
The Expression of Twist in Differentiated Thyroid Carcinomas
title The Expression of Twist in Differentiated Thyroid Carcinomas
title_full The Expression of Twist in Differentiated Thyroid Carcinomas
title_fullStr The Expression of Twist in Differentiated Thyroid Carcinomas
title_full_unstemmed The Expression of Twist in Differentiated Thyroid Carcinomas
title_short The Expression of Twist in Differentiated Thyroid Carcinomas
title_sort expression of twist in differentiated thyroid carcinomas
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340438/
https://www.ncbi.nlm.nih.gov/pubmed/25729603
http://dx.doi.org/10.12865/CHSJ.40.03.05
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