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Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery

The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the s...

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Detalles Bibliográficos
Autores principales: Bale, Gemma, Oliver-Taylor, Aaron, Fierens, Igor, Broad, Kevin, Hassell, Jane, Kawano, Go, Rostami, Jamshid, Raivich, Gennadij, Sanders, Robert, Robertson, Nicola, Tachtsidis, Ilias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer New York 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340574/
https://www.ncbi.nlm.nih.gov/pubmed/24729229
http://dx.doi.org/10.1007/978-1-4939-0620-8_22
Descripción
Sumario:The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the spontaneous changes in mean arterial blood pressure (MABP) on the cerebral haemodynamics (oxy- and deoxy-haemoglobin, HbO(2) and Hb) was measured using transverse broadband near-infrared spectroscopy (NIRS). A marker for impaired CA, concordance between MABP and intravascular oxygenation (HbD = HbO(2) − Hb) in the ultra-low frequency domain (0.0018–0.0083 Hz), was assessed using coherence analysis. Presence of CA impairment was not significant but found to increase with surgical exacerbation. The impairment did not correlate with histological outcome (presence of cell death, apoptosis and microglial activation in the brain).