Cargando…
Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery
The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the s...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer New York
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340574/ https://www.ncbi.nlm.nih.gov/pubmed/24729229 http://dx.doi.org/10.1007/978-1-4939-0620-8_22 |
_version_ | 1782359038019764224 |
---|---|
author | Bale, Gemma Oliver-Taylor, Aaron Fierens, Igor Broad, Kevin Hassell, Jane Kawano, Go Rostami, Jamshid Raivich, Gennadij Sanders, Robert Robertson, Nicola Tachtsidis, Ilias |
author_facet | Bale, Gemma Oliver-Taylor, Aaron Fierens, Igor Broad, Kevin Hassell, Jane Kawano, Go Rostami, Jamshid Raivich, Gennadij Sanders, Robert Robertson, Nicola Tachtsidis, Ilias |
author_sort | Bale, Gemma |
collection | PubMed |
description | The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the spontaneous changes in mean arterial blood pressure (MABP) on the cerebral haemodynamics (oxy- and deoxy-haemoglobin, HbO(2) and Hb) was measured using transverse broadband near-infrared spectroscopy (NIRS). A marker for impaired CA, concordance between MABP and intravascular oxygenation (HbD = HbO(2) − Hb) in the ultra-low frequency domain (0.0018–0.0083 Hz), was assessed using coherence analysis. Presence of CA impairment was not significant but found to increase with surgical exacerbation. The impairment did not correlate with histological outcome (presence of cell death, apoptosis and microglial activation in the brain). |
format | Online Article Text |
id | pubmed-4340574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer New York |
record_format | MEDLINE/PubMed |
spelling | pubmed-43405742015-02-25 Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery Bale, Gemma Oliver-Taylor, Aaron Fierens, Igor Broad, Kevin Hassell, Jane Kawano, Go Rostami, Jamshid Raivich, Gennadij Sanders, Robert Robertson, Nicola Tachtsidis, Ilias Adv Exp Med Biol Article The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the spontaneous changes in mean arterial blood pressure (MABP) on the cerebral haemodynamics (oxy- and deoxy-haemoglobin, HbO(2) and Hb) was measured using transverse broadband near-infrared spectroscopy (NIRS). A marker for impaired CA, concordance between MABP and intravascular oxygenation (HbD = HbO(2) − Hb) in the ultra-low frequency domain (0.0018–0.0083 Hz), was assessed using coherence analysis. Presence of CA impairment was not significant but found to increase with surgical exacerbation. The impairment did not correlate with histological outcome (presence of cell death, apoptosis and microglial activation in the brain). Springer New York 2014-03-22 /pmc/articles/PMC4340574/ /pubmed/24729229 http://dx.doi.org/10.1007/978-1-4939-0620-8_22 Text en © The Author(s) 2014 Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.The images or other third party material in this chapter are included in the chapter’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
spellingShingle | Article Bale, Gemma Oliver-Taylor, Aaron Fierens, Igor Broad, Kevin Hassell, Jane Kawano, Go Rostami, Jamshid Raivich, Gennadij Sanders, Robert Robertson, Nicola Tachtsidis, Ilias Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery |
title | Investigation of Cerebral Autoregulation in the Newborn Piglet
During Anaesthesia and Surgery |
title_full | Investigation of Cerebral Autoregulation in the Newborn Piglet
During Anaesthesia and Surgery |
title_fullStr | Investigation of Cerebral Autoregulation in the Newborn Piglet
During Anaesthesia and Surgery |
title_full_unstemmed | Investigation of Cerebral Autoregulation in the Newborn Piglet
During Anaesthesia and Surgery |
title_short | Investigation of Cerebral Autoregulation in the Newborn Piglet
During Anaesthesia and Surgery |
title_sort | investigation of cerebral autoregulation in the newborn piglet
during anaesthesia and surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340574/ https://www.ncbi.nlm.nih.gov/pubmed/24729229 http://dx.doi.org/10.1007/978-1-4939-0620-8_22 |
work_keys_str_mv | AT balegemma investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT olivertayloraaron investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT fierensigor investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT broadkevin investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT hasselljane investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT kawanogo investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT rostamijamshid investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT raivichgennadij investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT sandersrobert investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT robertsonnicola investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery AT tachtsidisilias investigationofcerebralautoregulationinthenewbornpigletduringanaesthesiaandsurgery |