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Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors
BACKGROUND: Metaplastic carcinoma of the breast (MCB) is a rare histological type of breast cancer. This study aimed to determine whether MCB exhibits shorter overall survival (OS) and disease-free survival (DFS) compared with other histologies that are considered unfavorable. METHODS: We retrospect...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340608/ https://www.ncbi.nlm.nih.gov/pubmed/25881163 http://dx.doi.org/10.1186/s12885-015-1079-2 |
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author | Barquet-Muñoz, Salim Abraham Villarreal-Colin, Silvia Patricia Herrera-Montalvo, Luis Alonso Soto-Reyes, Ernesto Pérez-Plasencia, Carlos Coronel-Martínez, Jaime Pérez-Montiel, Delia Vázquez-Romo, Rafael Cantú de León, David |
author_facet | Barquet-Muñoz, Salim Abraham Villarreal-Colin, Silvia Patricia Herrera-Montalvo, Luis Alonso Soto-Reyes, Ernesto Pérez-Plasencia, Carlos Coronel-Martínez, Jaime Pérez-Montiel, Delia Vázquez-Romo, Rafael Cantú de León, David |
author_sort | Barquet-Muñoz, Salim Abraham |
collection | PubMed |
description | BACKGROUND: Metaplastic carcinoma of the breast (MCB) is a rare histological type of breast cancer. This study aimed to determine whether MCB exhibits shorter overall survival (OS) and disease-free survival (DFS) compared with other histologies that are considered unfavorable. METHODS: We retrospectively analyzed 157 clinical file records of the Mexico City-based National Institute of Cancerology and compared the clinical characteristics and treatment of 24 patients with MCB, 37 patients with triple-negative invasive lobular carcinoma (TN-ILC), 48 patients with high-grade invasive ductal carcinoma (HG-IDC), and 48 patients with triple-negative invasive ductal carcinoma (TN-IDC), paired by clinical stage and age. We performed a comparative analysis and analyzed OS and DFS using a log-rank test. RESULTS: In patients with MCB, the 5-year DFS was 52.1% (mean, 48.52 months; 95%: 35.32-61.72), and the 5-year OS was 72.2% (mean, 59.77 months; 95% CI: 48.55-71.00). No differences were observed in the DFS of MCB compared with each of the other histologies (MCB vs. HG-IDC, p = 0.865; MCB vs. TN-IDC, p = 0.966, and MCB vs. TN-ILC, p = 0.132). Moreover, no differences were observed when comparing the OS of MCB with that of each of the other histologies (MCB vs. HG-IDC, p = 0.246; MCB vs. TN-IDC, p = 0.255, and MCB vs. TN-ILC, p = 0.387). CONCLUSIONS: Neither OS nor DFS differ between patients with MCB and those with other histologies with unfavorable immunohistochemical factors. |
format | Online Article Text |
id | pubmed-4340608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43406082015-02-26 Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors Barquet-Muñoz, Salim Abraham Villarreal-Colin, Silvia Patricia Herrera-Montalvo, Luis Alonso Soto-Reyes, Ernesto Pérez-Plasencia, Carlos Coronel-Martínez, Jaime Pérez-Montiel, Delia Vázquez-Romo, Rafael Cantú de León, David BMC Cancer Research Article BACKGROUND: Metaplastic carcinoma of the breast (MCB) is a rare histological type of breast cancer. This study aimed to determine whether MCB exhibits shorter overall survival (OS) and disease-free survival (DFS) compared with other histologies that are considered unfavorable. METHODS: We retrospectively analyzed 157 clinical file records of the Mexico City-based National Institute of Cancerology and compared the clinical characteristics and treatment of 24 patients with MCB, 37 patients with triple-negative invasive lobular carcinoma (TN-ILC), 48 patients with high-grade invasive ductal carcinoma (HG-IDC), and 48 patients with triple-negative invasive ductal carcinoma (TN-IDC), paired by clinical stage and age. We performed a comparative analysis and analyzed OS and DFS using a log-rank test. RESULTS: In patients with MCB, the 5-year DFS was 52.1% (mean, 48.52 months; 95%: 35.32-61.72), and the 5-year OS was 72.2% (mean, 59.77 months; 95% CI: 48.55-71.00). No differences were observed in the DFS of MCB compared with each of the other histologies (MCB vs. HG-IDC, p = 0.865; MCB vs. TN-IDC, p = 0.966, and MCB vs. TN-ILC, p = 0.132). Moreover, no differences were observed when comparing the OS of MCB with that of each of the other histologies (MCB vs. HG-IDC, p = 0.246; MCB vs. TN-IDC, p = 0.255, and MCB vs. TN-ILC, p = 0.387). CONCLUSIONS: Neither OS nor DFS differ between patients with MCB and those with other histologies with unfavorable immunohistochemical factors. BioMed Central 2015-02-20 /pmc/articles/PMC4340608/ /pubmed/25881163 http://dx.doi.org/10.1186/s12885-015-1079-2 Text en © Barquet-Muñoz et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Barquet-Muñoz, Salim Abraham Villarreal-Colin, Silvia Patricia Herrera-Montalvo, Luis Alonso Soto-Reyes, Ernesto Pérez-Plasencia, Carlos Coronel-Martínez, Jaime Pérez-Montiel, Delia Vázquez-Romo, Rafael Cantú de León, David Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors |
title | Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors |
title_full | Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors |
title_fullStr | Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors |
title_full_unstemmed | Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors |
title_short | Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors |
title_sort | metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340608/ https://www.ncbi.nlm.nih.gov/pubmed/25881163 http://dx.doi.org/10.1186/s12885-015-1079-2 |
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