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Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?

BACKGROUND: Artemisinin combination therapy (ACT) is first-line treatment for malaria in most endemic countries and is increasingly available in the private sector. Most studies on ACT adherence have been conducted in the public sector, with minimal data from private retailers. METHODS: Parallel stu...

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Autores principales: Bruxvoort, Katia, Kalolella, Admirabilis, Cairns, Matthew, Festo, Charles, Kenani, Mitya, Lyaruu, Peter, Kachur, S Patrick, Schellenberg, David, Goodman, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340668/
https://www.ncbi.nlm.nih.gov/pubmed/25889767
http://dx.doi.org/10.1186/s12936-015-0602-x
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author Bruxvoort, Katia
Kalolella, Admirabilis
Cairns, Matthew
Festo, Charles
Kenani, Mitya
Lyaruu, Peter
Kachur, S Patrick
Schellenberg, David
Goodman, Catherine
author_facet Bruxvoort, Katia
Kalolella, Admirabilis
Cairns, Matthew
Festo, Charles
Kenani, Mitya
Lyaruu, Peter
Kachur, S Patrick
Schellenberg, David
Goodman, Catherine
author_sort Bruxvoort, Katia
collection PubMed
description BACKGROUND: Artemisinin combination therapy (ACT) is first-line treatment for malaria in most endemic countries and is increasingly available in the private sector. Most studies on ACT adherence have been conducted in the public sector, with minimal data from private retailers. METHODS: Parallel studies were conducted in Tanzania, in which patients obtaining artemether-lumefantrine (AL) at 40 randomly selected public health facilities and 37 accredited drug dispensing outlets (ADDOs) were visited at home and questioned about doses taken. The effect of sector on adherence, controlling for potential confounders was assessed using logistic regression with a random effect for outlet. RESULTS: Of 572 health facility patients and 450 ADDO patients, 74.5% (95% CI: 69.8, 78.8) and 69.8% (95% CI: 64.6, 74.5), respectively, completed treatment and 46.0% (95% CI: 40.9, 51.2) and 34.8% (95% CI: 30.1, 39.8) took each dose at the correct time (‘timely completion’). ADDO patients were wealthier, more educated, older, sought care later in the day, and were less likely to test positive for malaria than health facility patients. Controlling for patient characteristics, the adjusted odds of completed treatment and of timely completion for ADDO patients were 0.65 (95% CI: 0.43, 1.00) and 0.69 (95% CI: 0.47, 1.01) times that of health facility patients. Higher socio-economic status was associated with both adherence measures. Higher education was associated with completed treatment (adjusted OR = 1.68, 95% CI: 1.20, 2.36); obtaining AL in the evening was associated with timely completion (adjusted OR = 0.35, 95% CI: 0.19, 0.64). Factors associated with adherence in each sector were examined separately. In both sectors, recalling correct instructions was positively associated with both adherence measures. In health facility patients, but not ADDO patients, taking the first dose of AL at the outlet was associated with timely completion (adjusted OR = 2.11, 95% CI: 1.46, 3.04). CONCLUSION: When controlling for patient characteristics, there was some evidence that the adjusted odds of adherence for ADDO patients was lower than that for public health facility patients. Better understanding is needed of which patient care aspects are most important for adherence, including the role of effective provision of advice. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12936-015-0602-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-43406682015-02-26 Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy? Bruxvoort, Katia Kalolella, Admirabilis Cairns, Matthew Festo, Charles Kenani, Mitya Lyaruu, Peter Kachur, S Patrick Schellenberg, David Goodman, Catherine Malar J Research BACKGROUND: Artemisinin combination therapy (ACT) is first-line treatment for malaria in most endemic countries and is increasingly available in the private sector. Most studies on ACT adherence have been conducted in the public sector, with minimal data from private retailers. METHODS: Parallel studies were conducted in Tanzania, in which patients obtaining artemether-lumefantrine (AL) at 40 randomly selected public health facilities and 37 accredited drug dispensing outlets (ADDOs) were visited at home and questioned about doses taken. The effect of sector on adherence, controlling for potential confounders was assessed using logistic regression with a random effect for outlet. RESULTS: Of 572 health facility patients and 450 ADDO patients, 74.5% (95% CI: 69.8, 78.8) and 69.8% (95% CI: 64.6, 74.5), respectively, completed treatment and 46.0% (95% CI: 40.9, 51.2) and 34.8% (95% CI: 30.1, 39.8) took each dose at the correct time (‘timely completion’). ADDO patients were wealthier, more educated, older, sought care later in the day, and were less likely to test positive for malaria than health facility patients. Controlling for patient characteristics, the adjusted odds of completed treatment and of timely completion for ADDO patients were 0.65 (95% CI: 0.43, 1.00) and 0.69 (95% CI: 0.47, 1.01) times that of health facility patients. Higher socio-economic status was associated with both adherence measures. Higher education was associated with completed treatment (adjusted OR = 1.68, 95% CI: 1.20, 2.36); obtaining AL in the evening was associated with timely completion (adjusted OR = 0.35, 95% CI: 0.19, 0.64). Factors associated with adherence in each sector were examined separately. In both sectors, recalling correct instructions was positively associated with both adherence measures. In health facility patients, but not ADDO patients, taking the first dose of AL at the outlet was associated with timely completion (adjusted OR = 2.11, 95% CI: 1.46, 3.04). CONCLUSION: When controlling for patient characteristics, there was some evidence that the adjusted odds of adherence for ADDO patients was lower than that for public health facility patients. Better understanding is needed of which patient care aspects are most important for adherence, including the role of effective provision of advice. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12936-015-0602-x) contains supplementary material, which is available to authorized users. BioMed Central 2015-02-19 /pmc/articles/PMC4340668/ /pubmed/25889767 http://dx.doi.org/10.1186/s12936-015-0602-x Text en © Bruxvoort et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Bruxvoort, Katia
Kalolella, Admirabilis
Cairns, Matthew
Festo, Charles
Kenani, Mitya
Lyaruu, Peter
Kachur, S Patrick
Schellenberg, David
Goodman, Catherine
Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
title Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
title_full Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
title_fullStr Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
title_full_unstemmed Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
title_short Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
title_sort are tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340668/
https://www.ncbi.nlm.nih.gov/pubmed/25889767
http://dx.doi.org/10.1186/s12936-015-0602-x
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