Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex

Gentamicin C complex is a mixture of aminoglycoside antibiotics used worldwide to treat severe Gram-negative bacterial infections. Despite its clinical importance, the enzymology of its biosynthetic pathway has remained obscure. We report here insights into the four enzyme-catalyzed steps that lead...

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Detalles Bibliográficos
Autores principales: Huang, Chuan, Huang, Fanglu, Moison, Eileen, Guo, Junhong, Jian, Xinyun, Duan, Xiaobo, Deng, Zixin, Leadlay, Peter F., Sun, Yuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340712/
https://www.ncbi.nlm.nih.gov/pubmed/25641167
http://dx.doi.org/10.1016/j.chembiol.2014.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340712/
https://www.ncbi.nlm.nih.gov/pubmed/25641167
http://dx.doi.org/10.1016/j.chembiol.2014.12.012

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