Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

Brain-derived neurotrophic factor (BDNF) plays a crucial role in modulating neural and behavioral plasticity to drugs of abuse. Here, we demonstrate a persistent down-regulation of exon-specific Bdnf expression in the ventral tegmental area (VTA) in response to chronic opiate exposure, which is medi...

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Detalles Bibliográficos
Autores principales: Koo, Ja Wook, Mazei-Robison, Michelle S., LaPlant, Quincey, Egervari, Gabor, Braunscheidel, Kevin M., Adank, Danielle N., Ferguson, Deveroux, Feng, Jian, Sun, Haosheng, Scobie, Kimberly N., Damez-Werno, Diane M., Ribeiro, Efrain, Peña, Catherine Jensen, Walker, Deena, Bagot, Rosemary C., Cahill, Michael E., Anderson, Sarah Ann R., Labonté, Benoit, Hodes, Georgia E., Browne, Heidi, Chadwick, Benjamin, Robison, Alfred J., Vialou, Vincent F., Dias, Caroline, Lorsch, Zachary, Mouzon, Ezekiell, Lobo, Mary Kay, Dietz, David M., Russo, Scott J., Neve, Rachael L., Hurd, Yasmin L., Nestler, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340719/
https://www.ncbi.nlm.nih.gov/pubmed/25643298
http://dx.doi.org/10.1038/nn.3932

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