Cargando…
Local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis
STUDY DESIGN: Prospective pilot study. OBJECTIVES: The aim of this study was to measure titanium, niobium and aluminium levels in various intraoperative and postoperative samples to determine patterns of metal ion release that occur within the first month following instrumented spinal fusion. SUMMAR...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340846/ https://www.ncbi.nlm.nih.gov/pubmed/25589286 http://dx.doi.org/10.1007/s11832-015-0631-6 |
_version_ | 1782359065742016512 |
---|---|
author | Cundy, William J. Mascarenhas, Annika R. Antoniou, Georgia Freeman, Brian J. C. Cundy, Peter J. |
author_facet | Cundy, William J. Mascarenhas, Annika R. Antoniou, Georgia Freeman, Brian J. C. Cundy, Peter J. |
author_sort | Cundy, William J. |
collection | PubMed |
description | STUDY DESIGN: Prospective pilot study. OBJECTIVES: The aim of this study was to measure titanium, niobium and aluminium levels in various intraoperative and postoperative samples to determine patterns of metal ion release that occur within the first month following instrumented spinal fusion. SUMMARY OF BACKGROUND DATA: Raised serum metal ion levels are reported following instrumented spinal fusion in adolescent idiopathic scoliosis. The exact topological origin and chronology of metal ion release remains conjectural. Recent literature suggests an immediate rise in serum metal levels within the first postoperative week. METHODS: Titanium, niobium and aluminium levels were measured before, during and after surgery in serum and local intraoperative fluid samples obtained from two pediatric patients undergoing posterior correction and instrumentation for scoliosis. RESULTS: Measurable metal ion levels were detected in all local samples obtained from wound irrigation fluid, cell saver blood, and fluid that immersed metal universal reduction screw tabs. Postoperative serum metal ion levels were elevated compared to baseline preoperative levels. In general, metal ion levels were considerably higher in the intraoperative fluid samples compared to those observed in the serum levels. CONCLUSION: Our findings of contextually high metal ion concentrations in intraoperative and early postoperative samples provide further empirical support of a ‘putting-in’ phenomenon of metal ion release following instrumented spinal fusion. This challenges existing beliefs that metal ion release occurs during an intermediate ‘wearing-in’ phase. We recommend thorough irrigation of the operative site prior to wound closure to dilute and remove intraoperative metal ion debris. Possibilities of filtering trace metal ions from cell saver content may be considered. |
format | Online Article Text |
id | pubmed-4340846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-43408462015-02-27 Local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis Cundy, William J. Mascarenhas, Annika R. Antoniou, Georgia Freeman, Brian J. C. Cundy, Peter J. J Child Orthop Original Clinical Article STUDY DESIGN: Prospective pilot study. OBJECTIVES: The aim of this study was to measure titanium, niobium and aluminium levels in various intraoperative and postoperative samples to determine patterns of metal ion release that occur within the first month following instrumented spinal fusion. SUMMARY OF BACKGROUND DATA: Raised serum metal ion levels are reported following instrumented spinal fusion in adolescent idiopathic scoliosis. The exact topological origin and chronology of metal ion release remains conjectural. Recent literature suggests an immediate rise in serum metal levels within the first postoperative week. METHODS: Titanium, niobium and aluminium levels were measured before, during and after surgery in serum and local intraoperative fluid samples obtained from two pediatric patients undergoing posterior correction and instrumentation for scoliosis. RESULTS: Measurable metal ion levels were detected in all local samples obtained from wound irrigation fluid, cell saver blood, and fluid that immersed metal universal reduction screw tabs. Postoperative serum metal ion levels were elevated compared to baseline preoperative levels. In general, metal ion levels were considerably higher in the intraoperative fluid samples compared to those observed in the serum levels. CONCLUSION: Our findings of contextually high metal ion concentrations in intraoperative and early postoperative samples provide further empirical support of a ‘putting-in’ phenomenon of metal ion release following instrumented spinal fusion. This challenges existing beliefs that metal ion release occurs during an intermediate ‘wearing-in’ phase. We recommend thorough irrigation of the operative site prior to wound closure to dilute and remove intraoperative metal ion debris. Possibilities of filtering trace metal ions from cell saver content may be considered. Springer Berlin Heidelberg 2015-01-15 2015-02 /pmc/articles/PMC4340846/ /pubmed/25589286 http://dx.doi.org/10.1007/s11832-015-0631-6 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Clinical Article Cundy, William J. Mascarenhas, Annika R. Antoniou, Georgia Freeman, Brian J. C. Cundy, Peter J. Local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis |
title | Local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis |
title_full | Local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis |
title_fullStr | Local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis |
title_full_unstemmed | Local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis |
title_short | Local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis |
title_sort | local and systemic metal ion release occurs intraoperatively during correction and instrumented spinal fusion for scoliosis |
topic | Original Clinical Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340846/ https://www.ncbi.nlm.nih.gov/pubmed/25589286 http://dx.doi.org/10.1007/s11832-015-0631-6 |
work_keys_str_mv | AT cundywilliamj localandsystemicmetalionreleaseoccursintraoperativelyduringcorrectionandinstrumentedspinalfusionforscoliosis AT mascarenhasannikar localandsystemicmetalionreleaseoccursintraoperativelyduringcorrectionandinstrumentedspinalfusionforscoliosis AT antoniougeorgia localandsystemicmetalionreleaseoccursintraoperativelyduringcorrectionandinstrumentedspinalfusionforscoliosis AT freemanbrianjc localandsystemicmetalionreleaseoccursintraoperativelyduringcorrectionandinstrumentedspinalfusionforscoliosis AT cundypeterj localandsystemicmetalionreleaseoccursintraoperativelyduringcorrectionandinstrumentedspinalfusionforscoliosis |