Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

Regulatory T (T(reg)) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of T(reg) cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression an...

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Detalles Bibliográficos
Autores principales: Medrikova, Dasa, Sijmonsma, Tjeerd P., Sowodniok, Katharina, Richards, David M., Delacher, Michael, Sticht, Carsten, Gretz, Norbert, Schafmeier, Tobias, Feuerer, Markus, Herzig, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340926/
https://www.ncbi.nlm.nih.gov/pubmed/25714366
http://dx.doi.org/10.1371/journal.pone.0118534
Descripción
Sumario:Regulatory T (T(reg)) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of T(reg) cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of T(reg) cells characterized by a unique gene signature. As these T(reg) cells respond to BAT activation upon cold exposure, this study defines a BAT-specific T(reg) sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

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