Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

Regulatory T (T(reg)) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of T(reg) cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression an...

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Autores principales: Medrikova, Dasa, Sijmonsma, Tjeerd P., Sowodniok, Katharina, Richards, David M., Delacher, Michael, Sticht, Carsten, Gretz, Norbert, Schafmeier, Tobias, Feuerer, Markus, Herzig, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340926/
https://www.ncbi.nlm.nih.gov/pubmed/25714366
http://dx.doi.org/10.1371/journal.pone.0118534
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author Medrikova, Dasa
Sijmonsma, Tjeerd P.
Sowodniok, Katharina
Richards, David M.
Delacher, Michael
Sticht, Carsten
Gretz, Norbert
Schafmeier, Tobias
Feuerer, Markus
Herzig, Stephan
author_facet Medrikova, Dasa
Sijmonsma, Tjeerd P.
Sowodniok, Katharina
Richards, David M.
Delacher, Michael
Sticht, Carsten
Gretz, Norbert
Schafmeier, Tobias
Feuerer, Markus
Herzig, Stephan
author_sort Medrikova, Dasa
collection PubMed
description Regulatory T (T(reg)) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of T(reg) cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of T(reg) cells characterized by a unique gene signature. As these T(reg) cells respond to BAT activation upon cold exposure, this study defines a BAT-specific T(reg) sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.
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spelling pubmed-43409262015-03-04 Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells Medrikova, Dasa Sijmonsma, Tjeerd P. Sowodniok, Katharina Richards, David M. Delacher, Michael Sticht, Carsten Gretz, Norbert Schafmeier, Tobias Feuerer, Markus Herzig, Stephan PLoS One Research Article Regulatory T (T(reg)) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of T(reg) cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of T(reg) cells characterized by a unique gene signature. As these T(reg) cells respond to BAT activation upon cold exposure, this study defines a BAT-specific T(reg) sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress. Public Library of Science 2015-02-25 /pmc/articles/PMC4340926/ /pubmed/25714366 http://dx.doi.org/10.1371/journal.pone.0118534 Text en © 2015 Medrikova et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Medrikova, Dasa
Sijmonsma, Tjeerd P.
Sowodniok, Katharina
Richards, David M.
Delacher, Michael
Sticht, Carsten
Gretz, Norbert
Schafmeier, Tobias
Feuerer, Markus
Herzig, Stephan
Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells
title Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells
title_full Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells
title_fullStr Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells
title_full_unstemmed Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells
title_short Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells
title_sort brown adipose tissue harbors a distinct sub-population of regulatory t cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340926/
https://www.ncbi.nlm.nih.gov/pubmed/25714366
http://dx.doi.org/10.1371/journal.pone.0118534
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