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Histidine 352 (His(352)) and Tryptophan 355 (Trp(355)) Are Essential for Flax UGT74S1 Glucosylation Activity toward Secoisolariciresinol

Flax secoisolariciresinol diglucoside (SDG) lignan is a natural phytoestrogen for which a positive role in metabolic diseases is emerging. Until recently however, much less was known about SDG and its monoglucoside (SMG) biosynthesis. Lately, flax UGT74S1 was identified and characterized as an enzym...

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Detalles Bibliográficos
Autores principales: Ghose, Kaushik, McCallum, Jason, Sweeney-Nixon, Marva, Fofana, Bourlaye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340967/
https://www.ncbi.nlm.nih.gov/pubmed/25714779
http://dx.doi.org/10.1371/journal.pone.0116248