Selection and characterization of llama single domain antibodies against N-terminal huntingtin

Huntington disease is caused by expansion of a CAG repeat in the huntingtin gene that is translated into an elongated polyglutamine stretch within the N-terminal domain of the huntingtin protein. The mutation is thought to introduce a gain-of-toxic function in the mutant huntingtin protein, and bloc...

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Detalles Bibliográficos
Autores principales: Schut, Menno H., Pepers, Barry A., Klooster, Rinse, van der Maarel, Silvère M., el Khatabi, Mohamed, Verrips, Theo, den Dunnen, Johan T., van Ommen, Gert-Jan B., van Roon-Mom, Willeke M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341019/
https://www.ncbi.nlm.nih.gov/pubmed/25294428
http://dx.doi.org/10.1007/s10072-014-1971-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341019/
https://www.ncbi.nlm.nih.gov/pubmed/25294428
http://dx.doi.org/10.1007/s10072-014-1971-6

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