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Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli

5-Aminolevulinic acid (ALA), the committed intermediate of the heme biosynthesis pathway, shows significant promise for cancer treatment. Here, we identified that in addition to hemA and hemL, hemB, hemD, hemF, hemG and hemH are also the major regulatory targets of the heme biosynthesis pathway. Int...

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Detalles Bibliográficos
Autores principales:	Zhang, Junli, Kang, Zhen, Chen, Jian, Du, Guocheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341193/ https://www.ncbi.nlm.nih.gov/pubmed/25716896 http://dx.doi.org/10.1038/srep08584

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