Cardioprotective activity of iron oxide nanoparticles

Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications and drug deliveries. However, the possibility whether they can be used as therapeutic drugs themselves has not yet been explored. We reported here that Fe(2)O(3) nanoparticles (NPs) can...

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Autores principales: Xiong, Fei, Wang, Hao, Feng, Yidong, Li, Yunman, Hua, Xiaoqing, Pang, Xingyun, Zhang, Song, Song, Lina, Zhang, Yu, Gu, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341209/
https://www.ncbi.nlm.nih.gov/pubmed/25716309
http://dx.doi.org/10.1038/srep08579
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author Xiong, Fei
Wang, Hao
Feng, Yidong
Li, Yunman
Hua, Xiaoqing
Pang, Xingyun
Zhang, Song
Song, Lina
Zhang, Yu
Gu, Ning
author_facet Xiong, Fei
Wang, Hao
Feng, Yidong
Li, Yunman
Hua, Xiaoqing
Pang, Xingyun
Zhang, Song
Song, Lina
Zhang, Yu
Gu, Ning
author_sort Xiong, Fei
collection PubMed
description Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications and drug deliveries. However, the possibility whether they can be used as therapeutic drugs themselves has not yet been explored. We reported here that Fe(2)O(3) nanoparticles (NPs) can protect hearts from ischemic damage at the animal, tissue and cell level. The cardioprotective activity of Fe(2)O(3) NPs requires the integrity of nanoparticles and is not dependent upon their surface charges and molecules that were integrated into nanoparticles. Also, Fe(2)O(3) NPs showed no significant toxicity towards normal cardiomyocytes, indicative of their potential to treat cardiovascular diseases.
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spelling pubmed-43412092015-03-04 Cardioprotective activity of iron oxide nanoparticles Xiong, Fei Wang, Hao Feng, Yidong Li, Yunman Hua, Xiaoqing Pang, Xingyun Zhang, Song Song, Lina Zhang, Yu Gu, Ning Sci Rep Article Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications and drug deliveries. However, the possibility whether they can be used as therapeutic drugs themselves has not yet been explored. We reported here that Fe(2)O(3) nanoparticles (NPs) can protect hearts from ischemic damage at the animal, tissue and cell level. The cardioprotective activity of Fe(2)O(3) NPs requires the integrity of nanoparticles and is not dependent upon their surface charges and molecules that were integrated into nanoparticles. Also, Fe(2)O(3) NPs showed no significant toxicity towards normal cardiomyocytes, indicative of their potential to treat cardiovascular diseases. Nature Publishing Group 2015-02-26 /pmc/articles/PMC4341209/ /pubmed/25716309 http://dx.doi.org/10.1038/srep08579 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Xiong, Fei
Wang, Hao
Feng, Yidong
Li, Yunman
Hua, Xiaoqing
Pang, Xingyun
Zhang, Song
Song, Lina
Zhang, Yu
Gu, Ning
Cardioprotective activity of iron oxide nanoparticles
title Cardioprotective activity of iron oxide nanoparticles
title_full Cardioprotective activity of iron oxide nanoparticles
title_fullStr Cardioprotective activity of iron oxide nanoparticles
title_full_unstemmed Cardioprotective activity of iron oxide nanoparticles
title_short Cardioprotective activity of iron oxide nanoparticles
title_sort cardioprotective activity of iron oxide nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341209/
https://www.ncbi.nlm.nih.gov/pubmed/25716309
http://dx.doi.org/10.1038/srep08579
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