Highly Stable and Sensitive Fluorescent Probes (LysoProbes) for Lysosomal Labeling and Tracking

We report the design, synthesis and application of several new fluorescent probes (LysoProbes I-VI) that facilitate lysosomal pH monitoring and characterization of lysosome-dependent apoptosis. LysoProbes are superior to commercially available lysosome markers since the fluorescent signals are both...

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Detalles Bibliográficos
Autores principales: Yapici, Nazmiye B., Bi, Yue, Li, Pengfei, Chen, Xin, Yan, Xin, Mandalapu, Srinivas Rao, Faucett, Megan, Jockusch, Steffen, Ju, Jingfang, Gibson, K. Michael, Pavan, William J., Bi, Lanrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341211/
https://www.ncbi.nlm.nih.gov/pubmed/25715948
http://dx.doi.org/10.1038/srep08576
Descripción
Sumario:We report the design, synthesis and application of several new fluorescent probes (LysoProbes I-VI) that facilitate lysosomal pH monitoring and characterization of lysosome-dependent apoptosis. LysoProbes are superior to commercially available lysosome markers since the fluorescent signals are both stable and highly selective, and they will aid in characterization of lysosome morphology and trafficking. We predict that labeling of cancer cells and solid tumor tissues with LysoProbes will provide an important new tool for monitoring the role of lysosome trafficking in cancer invasion and metastasis.

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