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Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state

BACKGROUND: This study was designed to determine relationship between the glucose metabolism disorder (the insulin resistance and the impaired glucose tolerance) and α-thalassemia. METHODS: In this historical cohort study, 80Alpha-thalassemia carriers and 80 healthy people were enrolled. The partici...

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Autores principales: Bahar, Adele, Shekarriz, Ramin, Janbabai, Ghasem, Shirzad, Roya, Aarabi, Mohsen, Kashi, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341229/
https://www.ncbi.nlm.nih.gov/pubmed/25722965
http://dx.doi.org/10.1186/s40200-015-0129-2
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author Bahar, Adele
Shekarriz, Ramin
Janbabai, Ghasem
Shirzad, Roya
Aarabi, Mohsen
Kashi, Zahra
author_facet Bahar, Adele
Shekarriz, Ramin
Janbabai, Ghasem
Shirzad, Roya
Aarabi, Mohsen
Kashi, Zahra
author_sort Bahar, Adele
collection PubMed
description BACKGROUND: This study was designed to determine relationship between the glucose metabolism disorder (the insulin resistance and the impaired glucose tolerance) and α-thalassemia. METHODS: In this historical cohort study, 80Alpha-thalassemia carriers and 80 healthy people were enrolled. The participants had no diabetes familial history and the waist circumference and blood pressure were in normal range (waist circumference of less than 102 cm in men, 88 cm in women and blood pressure <120/80 mmHg). The serum insulin level, fasting blood glucose (after 12 hours fasting) and two-hour plasma glucose during an oral glucose tolerance test (2-h OGTT) were measured. Insulin resistance was estimated according to homeostasis model assessment method (HOMA). Chi-square test, independent sample t-test and the relative risk were used for data analysis. RESULTS: According to FBS and OGTT results, the percentage of diabetes mellitus and pre-diabetes were 1.3% and 33.8% in Alpha-thalassemia carriers, respectively. The control group showed 2.5% diabetic and 13.8% pre-diabetic cases as well. The relative risk for the glucose tolerance impairment (diabetes and pre-diabetes) was 2.78 (95% CI: 1.31-5.88, P = 0.07).Six and a half percent of the Alpha-thalassemia group and 2.5% in the control group had 2.25 ≤ HOMAIR ≤ 3.59 (an intermediate state of Insulin sensitivity) p = 0.443. In the study, there was no subject with insulin resistance (HOMAIR >3.59). CONCLUSIONS: The possibility of risk enhancement of the impaired glucose tolerance (pre-diabetes and diabetes mellitus) in patients with α-thalassemia is almost three times greater than the normal population without relationship with insulin resistance. Diabetic and pre-diabetic Alpha-thalassemia carrier state is younger than the general population suffering of these disorders.
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spelling pubmed-43412292015-02-27 Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state Bahar, Adele Shekarriz, Ramin Janbabai, Ghasem Shirzad, Roya Aarabi, Mohsen Kashi, Zahra J Diabetes Metab Disord Research Article BACKGROUND: This study was designed to determine relationship between the glucose metabolism disorder (the insulin resistance and the impaired glucose tolerance) and α-thalassemia. METHODS: In this historical cohort study, 80Alpha-thalassemia carriers and 80 healthy people were enrolled. The participants had no diabetes familial history and the waist circumference and blood pressure were in normal range (waist circumference of less than 102 cm in men, 88 cm in women and blood pressure <120/80 mmHg). The serum insulin level, fasting blood glucose (after 12 hours fasting) and two-hour plasma glucose during an oral glucose tolerance test (2-h OGTT) were measured. Insulin resistance was estimated according to homeostasis model assessment method (HOMA). Chi-square test, independent sample t-test and the relative risk were used for data analysis. RESULTS: According to FBS and OGTT results, the percentage of diabetes mellitus and pre-diabetes were 1.3% and 33.8% in Alpha-thalassemia carriers, respectively. The control group showed 2.5% diabetic and 13.8% pre-diabetic cases as well. The relative risk for the glucose tolerance impairment (diabetes and pre-diabetes) was 2.78 (95% CI: 1.31-5.88, P = 0.07).Six and a half percent of the Alpha-thalassemia group and 2.5% in the control group had 2.25 ≤ HOMAIR ≤ 3.59 (an intermediate state of Insulin sensitivity) p = 0.443. In the study, there was no subject with insulin resistance (HOMAIR >3.59). CONCLUSIONS: The possibility of risk enhancement of the impaired glucose tolerance (pre-diabetes and diabetes mellitus) in patients with α-thalassemia is almost three times greater than the normal population without relationship with insulin resistance. Diabetic and pre-diabetic Alpha-thalassemia carrier state is younger than the general population suffering of these disorders. BioMed Central 2015-02-05 /pmc/articles/PMC4341229/ /pubmed/25722965 http://dx.doi.org/10.1186/s40200-015-0129-2 Text en © Bahar et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Bahar, Adele
Shekarriz, Ramin
Janbabai, Ghasem
Shirzad, Roya
Aarabi, Mohsen
Kashi, Zahra
Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state
title Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state
title_full Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state
title_fullStr Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state
title_full_unstemmed Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state
title_short Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state
title_sort insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341229/
https://www.ncbi.nlm.nih.gov/pubmed/25722965
http://dx.doi.org/10.1186/s40200-015-0129-2
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