Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆

A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This tr...

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Autores principales: Xie, Yunliang, Liu, Yanbo, Shen, Weigao, Zhang, Bo, Liu, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Gene Engineering and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341272/
https://www.ncbi.nlm.nih.gov/pubmed/25722690
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.13.008
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author Xie, Yunliang
Liu, Yanbo
Shen, Weigao
Zhang, Bo
Liu, Qun
author_facet Xie, Yunliang
Liu, Yanbo
Shen, Weigao
Zhang, Bo
Liu, Qun
author_sort Xie, Yunliang
collection PubMed
description A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibited the expression of the cell cycle regulatory proteins, survivin, cyclinD1, c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel.
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spelling pubmed-43412722015-02-26 Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆ Xie, Yunliang Liu, Yanbo Shen, Weigao Zhang, Bo Liu, Qun Neural Regen Res Research and Report: Gene Engineering and Neuroregeneration A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibited the expression of the cell cycle regulatory proteins, survivin, cyclinD1, c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel. Medknow Publications & Media Pvt Ltd 2012-05-05 /pmc/articles/PMC4341272/ /pubmed/25722690 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.13.008 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Gene Engineering and Neuroregeneration
Xie, Yunliang
Liu, Yanbo
Shen, Weigao
Zhang, Bo
Liu, Qun
Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆
title Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆
title_full Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆
title_fullStr Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆
title_full_unstemmed Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆
title_short Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆
title_sort survivin-specific small interfering rnas enhance sensitivity of glioma u-87mg cells to paclitaxel by promoting apoptosis☆
topic Research and Report: Gene Engineering and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341272/
https://www.ncbi.nlm.nih.gov/pubmed/25722690
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.13.008
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