Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★

Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate (MDHB; 2, 4, and 8 μM). Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression, and increased neuronal survival in a dose-depende...

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Autores principales: Zhang, Zheng, Zhou, Xing, Zhou, Xiaowen, Xu, Xiao, Liao, Minjing, Yan, Li, Lv, Ruohua, Luo, Huanmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Neurogensis and Neural Plasticicty
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341277/
https://www.ncbi.nlm.nih.gov/pubmed/25722684
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.13.002
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author Zhang, Zheng
Zhou, Xing
Zhou, Xiaowen
Xu, Xiao
Liao, Minjing
Yan, Li
Lv, Ruohua
Luo, Huanmin
author_facet Zhang, Zheng
Zhou, Xing
Zhou, Xiaowen
Xu, Xiao
Liao, Minjing
Yan, Li
Lv, Ruohua
Luo, Huanmin
author_sort Zhang, Zheng
collection PubMed
description Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate (MDHB; 2, 4, and 8 μM). Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression, and increased neuronal survival in a dose-dependent manner. Moreover, MDHB induced brain-derived neurotrophic factor expression. These findings suggest that MDHB has a neurotrophic effect, which may be due to its ability to increase brain-derived neurotrophic factor expression.
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spelling pubmed-43412772015-02-26 Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★ Zhang, Zheng Zhou, Xing Zhou, Xiaowen Xu, Xiao Liao, Minjing Yan, Li Lv, Ruohua Luo, Huanmin Neural Regen Res Research and Report: Neurogensis and Neural Plasticicty Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate (MDHB; 2, 4, and 8 μM). Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression, and increased neuronal survival in a dose-dependent manner. Moreover, MDHB induced brain-derived neurotrophic factor expression. These findings suggest that MDHB has a neurotrophic effect, which may be due to its ability to increase brain-derived neurotrophic factor expression. Medknow Publications & Media Pvt Ltd 2012-05-05 /pmc/articles/PMC4341277/ /pubmed/25722684 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.13.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Neurogensis and Neural Plasticicty
Zhang, Zheng
Zhou, Xing
Zhou, Xiaowen
Xu, Xiao
Liao, Minjing
Yan, Li
Lv, Ruohua
Luo, Huanmin
Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★
title Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★
title_full Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★
title_fullStr Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★
title_full_unstemmed Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★
title_short Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★
title_sort methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro★
topic Research and Report: Neurogensis and Neural Plasticicty
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341277/
https://www.ncbi.nlm.nih.gov/pubmed/25722684
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.13.002
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