Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★

Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100–4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment...

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Autores principales: Sun, Guifang, Yuan, Zhihao, Zhang, Boai, Jia, Yanjie, Ji, Yangfei, Ma, Xingrong, Liu, Yu, Liu, Yanru, Wen, Quanqing, Zhao, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Traditional Chinese Medicine and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341282/
https://www.ncbi.nlm.nih.gov/pubmed/25722671
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.12.002
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author Sun, Guifang
Yuan, Zhihao
Zhang, Boai
Jia, Yanjie
Ji, Yangfei
Ma, Xingrong
Liu, Yu
Liu, Yanru
Wen, Quanqing
Zhao, Yanling
author_facet Sun, Guifang
Yuan, Zhihao
Zhang, Boai
Jia, Yanjie
Ji, Yangfei
Ma, Xingrong
Liu, Yu
Liu, Yanru
Wen, Quanqing
Zhao, Yanling
author_sort Sun, Guifang
collection PubMed
description Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100–4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone. Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons.
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spelling pubmed-43412822015-02-26 Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★ Sun, Guifang Yuan, Zhihao Zhang, Boai Jia, Yanjie Ji, Yangfei Ma, Xingrong Liu, Yu Liu, Yanru Wen, Quanqing Zhao, Yanling Neural Regen Res Research and Report: Traditional Chinese Medicine and Neuroregeneration Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100–4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone. Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. Medknow Publications & Media Pvt Ltd 2012-04-25 /pmc/articles/PMC4341282/ /pubmed/25722671 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.12.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Traditional Chinese Medicine and Neuroregeneration
Sun, Guifang
Yuan, Zhihao
Zhang, Boai
Jia, Yanjie
Ji, Yangfei
Ma, Xingrong
Liu, Yu
Liu, Yanru
Wen, Quanqing
Zhao, Yanling
Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★
title Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★
title_full Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★
title_fullStr Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★
title_full_unstemmed Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★
title_short Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★
title_sort gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★
topic Research and Report: Traditional Chinese Medicine and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341282/
https://www.ncbi.nlm.nih.gov/pubmed/25722671
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.12.002
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