Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆

A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 c...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yanbo, Miao, Chunming, Wang, Zhenjiang, He, Xin, Shen, Weigao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Techniques and Methods: Gene Engineering and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341288/
https://www.ncbi.nlm.nih.gov/pubmed/25722677
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.12.008
Descripción
Sumario:A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro. In addition, treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo. Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma.

Ejemplares similares