Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆

A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 c...

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Autores principales: Liu, Yanbo, Miao, Chunming, Wang, Zhenjiang, He, Xin, Shen, Weigao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Techniques and Methods: Gene Engineering and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341288/
https://www.ncbi.nlm.nih.gov/pubmed/25722677
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.12.008
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author Liu, Yanbo
Miao, Chunming
Wang, Zhenjiang
He, Xin
Shen, Weigao
author_facet Liu, Yanbo
Miao, Chunming
Wang, Zhenjiang
He, Xin
Shen, Weigao
author_sort Liu, Yanbo
collection PubMed
description A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro. In addition, treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo. Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma.
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spelling pubmed-43412882015-02-26 Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆ Liu, Yanbo Miao, Chunming Wang, Zhenjiang He, Xin Shen, Weigao Neural Regen Res Techniques and Methods: Gene Engineering and Neuroregeneration A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro. In addition, treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo. Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma. Medknow Publications & Media Pvt Ltd 2012-04-25 /pmc/articles/PMC4341288/ /pubmed/25722677 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.12.008 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Techniques and Methods: Gene Engineering and Neuroregeneration
Liu, Yanbo
Miao, Chunming
Wang, Zhenjiang
He, Xin
Shen, Weigao
Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆
title Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆
title_full Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆
title_fullStr Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆
title_full_unstemmed Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆
title_short Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis☆
title_sort survivin small interfering rna suppresses glioblastoma growth by inducing cellular apoptosis☆
topic Techniques and Methods: Gene Engineering and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341288/
https://www.ncbi.nlm.nih.gov/pubmed/25722677
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.12.008
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AT wangzhenjiang survivinsmallinterferingrnasuppressesglioblastomagrowthbyinducingcellularapoptosis
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AT shenweigao survivinsmallinterferingrnasuppressesglioblastomagrowthbyinducingcellularapoptosis

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