Mania Induced by Opipramol

Antidepressants have propensity to induce manic switch in patients with bipolar disorder. Opipramol is an atypical anxiolytic and antidepressant drug which predominantly acts on sigma receptors. Although structurally resembles tricyclic antidepressant imipramine it does not have inhibitory action on...

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Autores principales: Firoz, Kazhungil, Khaleel, Asfia, Rajmohan, V, Kumar, Manoj, Raghuram, TM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341321/
https://www.ncbi.nlm.nih.gov/pubmed/25722522
http://dx.doi.org/10.4103/0253-7176.150852
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author Firoz, Kazhungil
Khaleel, Asfia
Rajmohan, V
Kumar, Manoj
Raghuram, TM
author_facet Firoz, Kazhungil
Khaleel, Asfia
Rajmohan, V
Kumar, Manoj
Raghuram, TM
author_sort Firoz, Kazhungil
collection PubMed
description Antidepressants have propensity to induce manic switch in patients with bipolar disorder. Opipramol is an atypical anxiolytic and antidepressant drug which predominantly acts on sigma receptors. Although structurally resembles tricyclic antidepressant imipramine it does not have inhibitory action on the reuptake of norepinephrine/serotonin and hence it is not presumed to cause manic switch in bipolar depression. Here, we describe a case of mania induced by opipramol, in a patient with bipolar affective disorder who was treated for moderate depressive episode with lithium and opipramol and we discuss neurochemical hypothesis of opipramol-induced mania.
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spelling pubmed-43413212015-02-26 Mania Induced by Opipramol Firoz, Kazhungil Khaleel, Asfia Rajmohan, V Kumar, Manoj Raghuram, TM Indian J Psychol Med Case Report Antidepressants have propensity to induce manic switch in patients with bipolar disorder. Opipramol is an atypical anxiolytic and antidepressant drug which predominantly acts on sigma receptors. Although structurally resembles tricyclic antidepressant imipramine it does not have inhibitory action on the reuptake of norepinephrine/serotonin and hence it is not presumed to cause manic switch in bipolar depression. Here, we describe a case of mania induced by opipramol, in a patient with bipolar affective disorder who was treated for moderate depressive episode with lithium and opipramol and we discuss neurochemical hypothesis of opipramol-induced mania. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4341321/ /pubmed/25722522 http://dx.doi.org/10.4103/0253-7176.150852 Text en Copyright: © Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Firoz, Kazhungil
Khaleel, Asfia
Rajmohan, V
Kumar, Manoj
Raghuram, TM
Mania Induced by Opipramol
title Mania Induced by Opipramol
title_full Mania Induced by Opipramol
title_fullStr Mania Induced by Opipramol
title_full_unstemmed Mania Induced by Opipramol
title_short Mania Induced by Opipramol
title_sort mania induced by opipramol
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341321/
https://www.ncbi.nlm.nih.gov/pubmed/25722522
http://dx.doi.org/10.4103/0253-7176.150852
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