Cargando…

Alpha-fetoprotein activates AKT/mTOR signaling to promote CXCR4 expression and migration of hepatoma cells

CXCR4, stromal cell-derived factor-1α(SDF 1α) receptor, stimulates growth and metastasis of hepatocellular carcinoma (HCC). Alpha-fetoprotein(AFP) governs the expression of some metastasis-related genes. Here we report that AFP and CXCR4 levels correlated in HCC tissues. AFP-expressing vectors induc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Mingyue, Guo, Junli, Xia, Hua, Li, Wei, Lu, Yan, Dong, Xu, Chen, Yi, Xie, Xieju, Fu, Shigan, Li, Mengsen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341465/ https://www.ncbi.nlm.nih.gov/pubmed/25815363

Ejemplares similares

Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells
por: Zhu, Mingyue, et al.
Publicado: (2015)

Alpha fetoprotein antagonizes apoptosis induced by paclitaxel in hepatoma cells in vitro
por: Zhu, Mingyue, et al.
Publicado: (2016)

HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver cells and hepatoma cells
por: Zhu, Mingyue, et al.
Publicado: (2015)

Hepatitis B Virus X Protein Driven Alpha Fetoprotein Expression to Promote Malignant Behaviors of Normal Liver Cells and Hepatoma Cells
por: Zhu, Mingyue, et al.
Publicado: (2016)

Hepatitis B Virus X Protein Driven Alpha Fetoprotein Expression to Promote Malignant Behaviors of Normal Liver Cells and Hepatoma Cells: Erratum
por: Zhu, Mingyue, et al.
Publicado: (2022)

Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling
por: Wang, Shanshan, et al.
Publicado: (2018)

Author Correction: Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling
por: Wang, Shanshan, et al.
Publicado: (2019)

Publisher Correction: Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling
por: Wang, Shanshan, et al.
Publicado: (2019)

Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells
por: Lu, Yan, et al.
Publicado: (2016)

α‐Fetoprotein fragment synergizes with sorafenib to inhibit hepatoma cell growth and migration and promote the apoptosis
por: Wang, Qiujiao, et al.
Publicado: (2022)

Alpha fetoprotein promotes polarization of macrophages towards M2-like phenotype and inhibits macrophages to phagocytize hepatoma cells
por: Zhang, Minni, et al.
Publicado: (2023)

Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells
por: Zhu, Mingyue, et al.
Publicado: (2016)

Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
por: Lin, Bo, et al.
Publicado: (2021)

Inhibition of synthesis of alpha-fetoprotein by glucocorticoids in cultured hepatoma cells
Publicado: (1982)

Expression and bioactivity of human α-fetoprotein in a Bac-to-Bac system
por: Lin, Bo, et al.
Publicado: (2017)

Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes
por: Li, Mengsen, et al.
Publicado: (2005)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Effects of chemotherapeutic agents on alpha-fetoprotein secretion and growth of human hepatoma cell lines in vitro.
por: Muraoka, A., et al.
Publicado: (1989)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Preoperative fibrinogen is associated with the clinical survival of primary liver cancer patients and promotes hepatoma metastasis via the PTEN/AKT/mTOR pathway
por: Qian, Xuemeng, et al.
Publicado: (2023)

CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells
por: Ieranò, C, et al.
Publicado: (2014)

CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2022)

Alpha-synuclein contributes to malignant progression of human meningioma via the Akt/mTOR pathway
por: Ge, Yiqin, et al.
Publicado: (2016)

CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR
por: Circelli, Luisa, et al.
Publicado: (2016)

Suppression of FAM83D Inhibits Glioma Proliferation, Invasion and Migration by Regulating the AKT/mTOR Signaling Pathway
por: Li, Xia, et al.
Publicado: (2022)

PODNL1 promotes cell proliferation and migration in glioma via regulating Akt/mTOR pathway
por: Geng, Yibo, et al.
Publicado: (2020)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Icaritin inhibits the expression of alpha-fetoprotein in hepatitis B virus-infected hepatoma cell lines through post-transcriptional regulation
por: Zhang, Chao, et al.
Publicado: (2016)

Correction for: CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2022)

Correction for: CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2023)

miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells
por: Gao, Rui, et al.
Publicado: (2015)

Sanguinarine inhibits melanoma invasion and migration by targeting the FAK/PI3K/AKT/mTOR signalling pathway
por: Qi, Xiaoyi, et al.
Publicado: (2023)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

Characterizations of Anti-Alpha-Fetoprotein-Conjugated Magnetic Nanoparticles Associated with Alpha-Fetoprotein for Biomedical Applications
por: Liao, Shu-Hsien, et al.
Publicado: (2017)

Deregulation of MicroRNA-375 Inhibits Proliferation and Migration in Gastric Cancer in Association With Autophagy-Mediated AKT/mTOR Signaling Pathways
por: Yuan, Kai-Tao, et al.
Publicado: (2018)

The m6A methyltransferase METTL14 inhibits the proliferation, migration, and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway
por: Liu, Xin, et al.
Publicado: (2020)

A novel peptide promotes human trophoblast proliferation and migration through PI3K/Akt/mTOR signaling pathway
por: Ling, Li, et al.
Publicado: (2021)

TRIM44 Promotes Colorectal Cancer Proliferation, Migration, and Invasion Through the Akt/mTOR Signaling Pathway
por: Li, Chun-guang, et al.
Publicado: (2019)

Icaritin Inhibits Migration and Invasion of Human Ovarian Cancer Cells via the Akt/mTOR Signaling Pathway
por: Gao, Lvfen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cf8cmin27bpccaonl7iial42t6