The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013). Here, we show by genome-wide in vivo ribosome profiling...

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Detalles Bibliográficos
Autores principales: Sidrauski, Carmela, McGeachy, Anna M, Ingolia, Nicholas T, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341466/
https://www.ncbi.nlm.nih.gov/pubmed/25719440
http://dx.doi.org/10.7554/eLife.05033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341466/
https://www.ncbi.nlm.nih.gov/pubmed/25719440
http://dx.doi.org/10.7554/eLife.05033

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