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Phase-dependent modulation as a novel approach for therapeutic brain stimulation

Closed-loop paradigms provide us with the opportunity to optimize stimulation protocols for perturbation of pathological oscillatory activity in brain-related disorders. In this vein, spiking activity of motor cortex neurons and beta activity of local field potentials in the subthalamic nucleus have...

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Autores principales: Azodi-Avval, Ramin, Gharabaghi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341563/
https://www.ncbi.nlm.nih.gov/pubmed/25767446
http://dx.doi.org/10.3389/fncom.2015.00026
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author Azodi-Avval, Ramin
Gharabaghi, Alireza
author_facet Azodi-Avval, Ramin
Gharabaghi, Alireza
author_sort Azodi-Avval, Ramin
collection PubMed
description Closed-loop paradigms provide us with the opportunity to optimize stimulation protocols for perturbation of pathological oscillatory activity in brain-related disorders. In this vein, spiking activity of motor cortex neurons and beta activity of local field potentials in the subthalamic nucleus have both been used independently of each other as neuronal signals to trigger deep brain stimulation for alleviating Parkinsonism. These approaches were superior to the standard continuous high-frequency stimulation protocols used in daily practice. However, they achieved their effects by bursts of stimulation that were applied at high-frequency as well, i.e., independent of the phase information in the stimulated region. In this context, we propose that, by timing stimulation pulses relative to the ongoing oscillation, an alternative approach, namely the targeted perturbation of pathological rhythms, could be obtained. In this modeling study, we first captured the underlying dynamics of neuronal oscillations in the human subthalamic nucleus by phased coupled neuronal oscillators. We then quantified the nature of the interaction between these coupled oscillators by obtaining a physiologically informed phase response curve from local field potentials. Reconstruction of the phase response curve predicted the sensitivity of the phase oscillator to external stimuli, revealing phase intervals that optimally maximized the degree of perturbation. We conclude that our specifically timed intervention based on the coupled oscillator concept will enable us to identify personalized ways of delivering stimulation pulses in closed-loop paradigms triggered by the phase of pathological oscillations. This will pave the way for novel physiological insights and substantial clinical benefits. In addition, this precisely phased modulation may be capable of modifying the effective interactions between oscillators in an entirely new manner.
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spelling pubmed-43415632015-03-12 Phase-dependent modulation as a novel approach for therapeutic brain stimulation Azodi-Avval, Ramin Gharabaghi, Alireza Front Comput Neurosci Neuroscience Closed-loop paradigms provide us with the opportunity to optimize stimulation protocols for perturbation of pathological oscillatory activity in brain-related disorders. In this vein, spiking activity of motor cortex neurons and beta activity of local field potentials in the subthalamic nucleus have both been used independently of each other as neuronal signals to trigger deep brain stimulation for alleviating Parkinsonism. These approaches were superior to the standard continuous high-frequency stimulation protocols used in daily practice. However, they achieved their effects by bursts of stimulation that were applied at high-frequency as well, i.e., independent of the phase information in the stimulated region. In this context, we propose that, by timing stimulation pulses relative to the ongoing oscillation, an alternative approach, namely the targeted perturbation of pathological rhythms, could be obtained. In this modeling study, we first captured the underlying dynamics of neuronal oscillations in the human subthalamic nucleus by phased coupled neuronal oscillators. We then quantified the nature of the interaction between these coupled oscillators by obtaining a physiologically informed phase response curve from local field potentials. Reconstruction of the phase response curve predicted the sensitivity of the phase oscillator to external stimuli, revealing phase intervals that optimally maximized the degree of perturbation. We conclude that our specifically timed intervention based on the coupled oscillator concept will enable us to identify personalized ways of delivering stimulation pulses in closed-loop paradigms triggered by the phase of pathological oscillations. This will pave the way for novel physiological insights and substantial clinical benefits. In addition, this precisely phased modulation may be capable of modifying the effective interactions between oscillators in an entirely new manner. Frontiers Media S.A. 2015-02-26 /pmc/articles/PMC4341563/ /pubmed/25767446 http://dx.doi.org/10.3389/fncom.2015.00026 Text en Copyright © 2015 Azodi-Avval and Gharabaghi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Azodi-Avval, Ramin
Gharabaghi, Alireza
Phase-dependent modulation as a novel approach for therapeutic brain stimulation
title Phase-dependent modulation as a novel approach for therapeutic brain stimulation
title_full Phase-dependent modulation as a novel approach for therapeutic brain stimulation
title_fullStr Phase-dependent modulation as a novel approach for therapeutic brain stimulation
title_full_unstemmed Phase-dependent modulation as a novel approach for therapeutic brain stimulation
title_short Phase-dependent modulation as a novel approach for therapeutic brain stimulation
title_sort phase-dependent modulation as a novel approach for therapeutic brain stimulation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341563/
https://www.ncbi.nlm.nih.gov/pubmed/25767446
http://dx.doi.org/10.3389/fncom.2015.00026
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