Cargando…

Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena

Facial skin ageing is caused by intrinsic and extrinsic mechanisms. Intrinsic ageing is highly related to chronological age. Age related skin changes can be measured using clinical and biophysical methods. The aim of this study was to evaluate whether and how clinical characteristics and biophysical...

Descripción completa

Detalles Bibliográficos
Autores principales: Trojahn, Carina, Dobos, Gabor, Lichterfeld, Andrea, Blume-Peytavi, Ulrike, Kottner, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341846/
https://www.ncbi.nlm.nih.gov/pubmed/25767806
http://dx.doi.org/10.1155/2015/318586
_version_ 1782359211262345216
author Trojahn, Carina
Dobos, Gabor
Lichterfeld, Andrea
Blume-Peytavi, Ulrike
Kottner, Jan
author_facet Trojahn, Carina
Dobos, Gabor
Lichterfeld, Andrea
Blume-Peytavi, Ulrike
Kottner, Jan
author_sort Trojahn, Carina
collection PubMed
description Facial skin ageing is caused by intrinsic and extrinsic mechanisms. Intrinsic ageing is highly related to chronological age. Age related skin changes can be measured using clinical and biophysical methods. The aim of this study was to evaluate whether and how clinical characteristics and biophysical parameters are associated with each other with and without adjustment for chronological age. Twenty-four female subjects of three age groups were enrolled. Clinical assessments (global facial skin ageing, wrinkling, and sagging), and biophysical measurements (roughness, colour, skin elasticity, and barrier function) were conducted at both upper cheeks. Pearson's correlations and linear regression models adjusted for age were calculated. Most of the measured parameters were correlated with chronological age (e.g., association with wrinkle score, r = 0.901) and with each other (e.g., residual skin deformation and wrinkle score, r = 0.606). After statistical adjustment for age, only few associations remained (e.g., mean roughness (R (z)) and luminance (L (*)),  β = −0.507, R (2) = 0.377). Chronological age as surrogate marker for intrinsic ageing has the most important influence on most facial skin ageing signs. Changes in skin elasticity, wrinkling, sagging, and yellowness seem to be caused by additional extrinsic ageing.
format Online
Article
Text
id pubmed-4341846
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43418462015-03-12 Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena Trojahn, Carina Dobos, Gabor Lichterfeld, Andrea Blume-Peytavi, Ulrike Kottner, Jan Biomed Res Int Research Article Facial skin ageing is caused by intrinsic and extrinsic mechanisms. Intrinsic ageing is highly related to chronological age. Age related skin changes can be measured using clinical and biophysical methods. The aim of this study was to evaluate whether and how clinical characteristics and biophysical parameters are associated with each other with and without adjustment for chronological age. Twenty-four female subjects of three age groups were enrolled. Clinical assessments (global facial skin ageing, wrinkling, and sagging), and biophysical measurements (roughness, colour, skin elasticity, and barrier function) were conducted at both upper cheeks. Pearson's correlations and linear regression models adjusted for age were calculated. Most of the measured parameters were correlated with chronological age (e.g., association with wrinkle score, r = 0.901) and with each other (e.g., residual skin deformation and wrinkle score, r = 0.606). After statistical adjustment for age, only few associations remained (e.g., mean roughness (R (z)) and luminance (L (*)),  β = −0.507, R (2) = 0.377). Chronological age as surrogate marker for intrinsic ageing has the most important influence on most facial skin ageing signs. Changes in skin elasticity, wrinkling, sagging, and yellowness seem to be caused by additional extrinsic ageing. Hindawi Publishing Corporation 2015 2015-02-12 /pmc/articles/PMC4341846/ /pubmed/25767806 http://dx.doi.org/10.1155/2015/318586 Text en Copyright © 2015 Carina Trojahn et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Trojahn, Carina
Dobos, Gabor
Lichterfeld, Andrea
Blume-Peytavi, Ulrike
Kottner, Jan
Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena
title Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena
title_full Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena
title_fullStr Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena
title_full_unstemmed Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena
title_short Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena
title_sort characterizing facial skin ageing in humans: disentangling extrinsic from intrinsic biological phenomena
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341846/
https://www.ncbi.nlm.nih.gov/pubmed/25767806
http://dx.doi.org/10.1155/2015/318586
work_keys_str_mv AT trojahncarina characterizingfacialskinageinginhumansdisentanglingextrinsicfromintrinsicbiologicalphenomena
AT dobosgabor characterizingfacialskinageinginhumansdisentanglingextrinsicfromintrinsicbiologicalphenomena
AT lichterfeldandrea characterizingfacialskinageinginhumansdisentanglingextrinsicfromintrinsicbiologicalphenomena
AT blumepeytaviulrike characterizingfacialskinageinginhumansdisentanglingextrinsicfromintrinsicbiologicalphenomena
AT kottnerjan characterizingfacialskinageinginhumansdisentanglingextrinsicfromintrinsicbiologicalphenomena