A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

Embryos allocate cells to the three germ layers in a spatially ordered sequence. Human embryonic stem cells (hESCs) can generate the three germ layers in culture, however, differentiation is typically heterogeneous and spatially disordered. Here we show that geometric confinement is sufficient to tr...

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Detalles Bibliográficos
Autores principales: Warmflash, Aryeh, Sorre, Benoit, Etoc, Fred, Siggia, Eric D., Brivanlou, Ali H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341966/
https://www.ncbi.nlm.nih.gov/pubmed/24973948
http://dx.doi.org/10.1038/nmeth.3016

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