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Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

Objective. The aim of this study was to review HIV-negative patients with pulmonary cryptococcosis to analyze the correlations between clinical characteristics and chest computed tomography (CT) findings. Methods. We retrospectively analyzed medical records of 16 HIV-negative patients with pulmonary...

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Autores principales: Yamakawa, Hideaki, Yoshida, Masahiro, Yabe, Masami, Baba, Emiri, Okuda, Keitaro, Fujimoto, Shota, Katagi, Hiroaki, Ishikawa, Takeo, Takagi, Masamichi, Kuwano, Kazuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342071/
https://www.ncbi.nlm.nih.gov/pubmed/25767722
http://dx.doi.org/10.1155/2015/703407
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author Yamakawa, Hideaki
Yoshida, Masahiro
Yabe, Masami
Baba, Emiri
Okuda, Keitaro
Fujimoto, Shota
Katagi, Hiroaki
Ishikawa, Takeo
Takagi, Masamichi
Kuwano, Kazuyoshi
author_facet Yamakawa, Hideaki
Yoshida, Masahiro
Yabe, Masami
Baba, Emiri
Okuda, Keitaro
Fujimoto, Shota
Katagi, Hiroaki
Ishikawa, Takeo
Takagi, Masamichi
Kuwano, Kazuyoshi
author_sort Yamakawa, Hideaki
collection PubMed
description Objective. The aim of this study was to review HIV-negative patients with pulmonary cryptococcosis to analyze the correlations between clinical characteristics and chest computed tomography (CT) findings. Methods. We retrospectively analyzed medical records of 16 HIV-negative patients with pulmonary cryptococcosis diagnosed at our institution, and clinical characteristics of the patients with nodules or masses without ground-glass attenuation (GGA)/consolidation type were compared with those of patients with inclusive GGA or consolidation type. Results. Host status was immunocompromised (81.2%) in most of the patients, and 6 (37.5%) were asymptomatic. The most frequent radiologic abnormalities on chest CT scans were one or more nodules (87.5%), GGA (37.5%), and consolidations (18.8%). Most lesions were located in the lower lung. Levels of hemoglobin and platelets were significantly lower in patients with inclusive GGA or consolidation type. Although the differences were not significant, patients with inclusive GGA or consolidation type tended to have a C-reactive protein level of ≥1.0 mg/dL. Conclusion. If a patient with anemia and thrombocytopenia shows GGA or consolidation in the lung, pulmonary cryptococcosis should be given careful consideration.
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spelling pubmed-43420712015-03-12 Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis Yamakawa, Hideaki Yoshida, Masahiro Yabe, Masami Baba, Emiri Okuda, Keitaro Fujimoto, Shota Katagi, Hiroaki Ishikawa, Takeo Takagi, Masamichi Kuwano, Kazuyoshi Pulm Med Review Article Objective. The aim of this study was to review HIV-negative patients with pulmonary cryptococcosis to analyze the correlations between clinical characteristics and chest computed tomography (CT) findings. Methods. We retrospectively analyzed medical records of 16 HIV-negative patients with pulmonary cryptococcosis diagnosed at our institution, and clinical characteristics of the patients with nodules or masses without ground-glass attenuation (GGA)/consolidation type were compared with those of patients with inclusive GGA or consolidation type. Results. Host status was immunocompromised (81.2%) in most of the patients, and 6 (37.5%) were asymptomatic. The most frequent radiologic abnormalities on chest CT scans were one or more nodules (87.5%), GGA (37.5%), and consolidations (18.8%). Most lesions were located in the lower lung. Levels of hemoglobin and platelets were significantly lower in patients with inclusive GGA or consolidation type. Although the differences were not significant, patients with inclusive GGA or consolidation type tended to have a C-reactive protein level of ≥1.0 mg/dL. Conclusion. If a patient with anemia and thrombocytopenia shows GGA or consolidation in the lung, pulmonary cryptococcosis should be given careful consideration. Hindawi Publishing Corporation 2015 2015-02-12 /pmc/articles/PMC4342071/ /pubmed/25767722 http://dx.doi.org/10.1155/2015/703407 Text en Copyright © 2015 Hideaki Yamakawa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yamakawa, Hideaki
Yoshida, Masahiro
Yabe, Masami
Baba, Emiri
Okuda, Keitaro
Fujimoto, Shota
Katagi, Hiroaki
Ishikawa, Takeo
Takagi, Masamichi
Kuwano, Kazuyoshi
Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis
title Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis
title_full Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis
title_fullStr Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis
title_full_unstemmed Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis
title_short Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis
title_sort correlation between clinical characteristics and chest computed tomography findings of pulmonary cryptococcosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342071/
https://www.ncbi.nlm.nih.gov/pubmed/25767722
http://dx.doi.org/10.1155/2015/703407
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