Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case

A 45-year-old female was diagnosed as having lung adenocarcinoma harboring an anaplastic lymphoma kinase (ALK) rearrangement, stage IV (T2bN3M1b). She was treated with crizotinib as second-line chemotherapy. The clinical stage after crizotinib treatment was ycT2aN0M0, stage IB. We performed a left l...

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Autores principales: Kaseda, Kaoru, Watanabe, Ken-ichi, Asakura, Keisuke, Kazama, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342155/
https://www.ncbi.nlm.nih.gov/pubmed/25889062
http://dx.doi.org/10.1186/s12957-015-0480-2
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author Kaseda, Kaoru
Watanabe, Ken-ichi
Asakura, Keisuke
Kazama, Akio
author_facet Kaseda, Kaoru
Watanabe, Ken-ichi
Asakura, Keisuke
Kazama, Akio
author_sort Kaseda, Kaoru
collection PubMed
description A 45-year-old female was diagnosed as having lung adenocarcinoma harboring an anaplastic lymphoma kinase (ALK) rearrangement, stage IV (T2bN3M1b). She was treated with crizotinib as second-line chemotherapy. The clinical stage after crizotinib treatment was ycT2aN0M0, stage IB. We performed a left lower lobectomy and lymph node dissection aimed at local control and pathological confirmation of the remaining tumor. The final pathological stage was ypT2aN2M0, stage IIIA with Ef 1b. To the best of our knowledge, this is the first case report of surgical resection in ALK rearrangement-positive lung adenocarcinoma after crizotinib treatment.
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spelling pubmed-43421552015-02-27 Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case Kaseda, Kaoru Watanabe, Ken-ichi Asakura, Keisuke Kazama, Akio World J Surg Oncol Case Report A 45-year-old female was diagnosed as having lung adenocarcinoma harboring an anaplastic lymphoma kinase (ALK) rearrangement, stage IV (T2bN3M1b). She was treated with crizotinib as second-line chemotherapy. The clinical stage after crizotinib treatment was ycT2aN0M0, stage IB. We performed a left lower lobectomy and lymph node dissection aimed at local control and pathological confirmation of the remaining tumor. The final pathological stage was ypT2aN2M0, stage IIIA with Ef 1b. To the best of our knowledge, this is the first case report of surgical resection in ALK rearrangement-positive lung adenocarcinoma after crizotinib treatment. BioMed Central 2015-02-22 /pmc/articles/PMC4342155/ /pubmed/25889062 http://dx.doi.org/10.1186/s12957-015-0480-2 Text en © Kaseda et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kaseda, Kaoru
Watanabe, Ken-ichi
Asakura, Keisuke
Kazama, Akio
Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case
title Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case
title_full Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case
title_fullStr Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case
title_full_unstemmed Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case
title_short Surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case
title_sort surgical resection of lung adenocarcinoma after crizotinib treatment: report of a case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342155/
https://www.ncbi.nlm.nih.gov/pubmed/25889062
http://dx.doi.org/10.1186/s12957-015-0480-2
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