Cargando…

Fan-Shaped Complete Block on Helical Tomotherapy for Esophageal Cancer: A Phantom Study

Radiation pneumonitis (RP) is a common complication for radiotherapy of esophageal cancer and is associated with the low dose irradiated lung volume. This study aims to reduce the mean lung dose (MLD) and the relative lung volume at 20 Gy (V (20)) and at low dose region using various designs of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Chiu-Han, Mok, Greta S. P., Shueng, Pei-Wei, Yeh, Hsin-Pei, Shiau, An-Cheng, Tien, Hui-Ju, Lin, Chi-Ta, Wu, Tung-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342177/
https://www.ncbi.nlm.nih.gov/pubmed/25767810
http://dx.doi.org/10.1155/2015/959504
_version_ 1782359246946435072
author Chang, Chiu-Han
Mok, Greta S. P.
Shueng, Pei-Wei
Yeh, Hsin-Pei
Shiau, An-Cheng
Tien, Hui-Ju
Lin, Chi-Ta
Wu, Tung-Hsin
author_facet Chang, Chiu-Han
Mok, Greta S. P.
Shueng, Pei-Wei
Yeh, Hsin-Pei
Shiau, An-Cheng
Tien, Hui-Ju
Lin, Chi-Ta
Wu, Tung-Hsin
author_sort Chang, Chiu-Han
collection PubMed
description Radiation pneumonitis (RP) is a common complication for radiotherapy of esophageal cancer and is associated with the low dose irradiated lung volume. This study aims to reduce the mean lung dose (MLD) and the relative lung volume at 20 Gy (V (20)) and at low dose region using various designs of the fan-shaped complete block (FSCB) in helical tomotherapy. Hypothetical esophageal tumor was delineated on an anthropomorphic phantom. The FSCB was defined as the fan-shaped radiation restricted area located in both lungs. Seven treatment plans were performed with nonblock design and FSCB with different fan angles, that is, from 90° to 140°, with increment of 10°. The homogeneous index, conformation number, MLD, and the relative lung volume receiving more than 5, 10, 15, and 20 Gy (V (5), V (10), V (15), and V (20)) were determined for each treatment scheme. There was a substantial reduction in the MLD, V (5), V (10), V (15), and V (20) when using different types of FSCB as compared to the nonblock design. The reduction of V (20), V (15), V (10), and V (5) was 6.3%–8.6%, 16%–23%, 42%–57%, and 42%–66% for FSCB 90°–140°, respectively. The use of FSCB in helical tomotherapy is a promising method to reduce the MLD, V (20), and relative lung volume in low dose region, especially in V (5) and V (10) for esophageal cancer.
format Online
Article
Text
id pubmed-4342177
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43421772015-03-12 Fan-Shaped Complete Block on Helical Tomotherapy for Esophageal Cancer: A Phantom Study Chang, Chiu-Han Mok, Greta S. P. Shueng, Pei-Wei Yeh, Hsin-Pei Shiau, An-Cheng Tien, Hui-Ju Lin, Chi-Ta Wu, Tung-Hsin Biomed Res Int Research Article Radiation pneumonitis (RP) is a common complication for radiotherapy of esophageal cancer and is associated with the low dose irradiated lung volume. This study aims to reduce the mean lung dose (MLD) and the relative lung volume at 20 Gy (V (20)) and at low dose region using various designs of the fan-shaped complete block (FSCB) in helical tomotherapy. Hypothetical esophageal tumor was delineated on an anthropomorphic phantom. The FSCB was defined as the fan-shaped radiation restricted area located in both lungs. Seven treatment plans were performed with nonblock design and FSCB with different fan angles, that is, from 90° to 140°, with increment of 10°. The homogeneous index, conformation number, MLD, and the relative lung volume receiving more than 5, 10, 15, and 20 Gy (V (5), V (10), V (15), and V (20)) were determined for each treatment scheme. There was a substantial reduction in the MLD, V (5), V (10), V (15), and V (20) when using different types of FSCB as compared to the nonblock design. The reduction of V (20), V (15), V (10), and V (5) was 6.3%–8.6%, 16%–23%, 42%–57%, and 42%–66% for FSCB 90°–140°, respectively. The use of FSCB in helical tomotherapy is a promising method to reduce the MLD, V (20), and relative lung volume in low dose region, especially in V (5) and V (10) for esophageal cancer. Hindawi Publishing Corporation 2015 2015-02-12 /pmc/articles/PMC4342177/ /pubmed/25767810 http://dx.doi.org/10.1155/2015/959504 Text en Copyright © 2015 Chiu-Han Chang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chang, Chiu-Han
Mok, Greta S. P.
Shueng, Pei-Wei
Yeh, Hsin-Pei
Shiau, An-Cheng
Tien, Hui-Ju
Lin, Chi-Ta
Wu, Tung-Hsin
Fan-Shaped Complete Block on Helical Tomotherapy for Esophageal Cancer: A Phantom Study
title Fan-Shaped Complete Block on Helical Tomotherapy for Esophageal Cancer: A Phantom Study
title_full Fan-Shaped Complete Block on Helical Tomotherapy for Esophageal Cancer: A Phantom Study
title_fullStr Fan-Shaped Complete Block on Helical Tomotherapy for Esophageal Cancer: A Phantom Study
title_full_unstemmed Fan-Shaped Complete Block on Helical Tomotherapy for Esophageal Cancer: A Phantom Study
title_short Fan-Shaped Complete Block on Helical Tomotherapy for Esophageal Cancer: A Phantom Study
title_sort fan-shaped complete block on helical tomotherapy for esophageal cancer: a phantom study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342177/
https://www.ncbi.nlm.nih.gov/pubmed/25767810
http://dx.doi.org/10.1155/2015/959504
work_keys_str_mv AT changchiuhan fanshapedcompleteblockonhelicaltomotherapyforesophagealcanceraphantomstudy
AT mokgretasp fanshapedcompleteblockonhelicaltomotherapyforesophagealcanceraphantomstudy
AT shuengpeiwei fanshapedcompleteblockonhelicaltomotherapyforesophagealcanceraphantomstudy
AT yehhsinpei fanshapedcompleteblockonhelicaltomotherapyforesophagealcanceraphantomstudy
AT shiauancheng fanshapedcompleteblockonhelicaltomotherapyforesophagealcanceraphantomstudy
AT tienhuiju fanshapedcompleteblockonhelicaltomotherapyforesophagealcanceraphantomstudy
AT linchita fanshapedcompleteblockonhelicaltomotherapyforesophagealcanceraphantomstudy
AT wutunghsin fanshapedcompleteblockonhelicaltomotherapyforesophagealcanceraphantomstudy