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Probabilities of Fitness Consequences for Point Mutations Across the Human Genome
We describe a novel computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These fitness consequence (fitCons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster genomic positions...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342276/ https://www.ncbi.nlm.nih.gov/pubmed/25599402 http://dx.doi.org/10.1038/ng.3196 |