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Probabilities of Fitness Consequences for Point Mutations Across the Human Genome

We describe a novel computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These fitness consequence (fitCons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster genomic positions...

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Detalles Bibliográficos
Autores principales:	Gulko, Brad, Hubisz, Melissa J., Gronau, Ilan, Siepel, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342276/ https://www.ncbi.nlm.nih.gov/pubmed/25599402 http://dx.doi.org/10.1038/ng.3196

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