Cargando…

Efficient Bayesian mixed model analysis increases association power in large cohorts

Linear mixed models are a powerful statistical tool for identifying genetic associations and avoiding confounding. However, existing methods are computationally intractable in large cohorts, and may not optimize power. All existing methods require time cost O(MN(2)) (where N = #samples and M = #SNPs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Loh, Po-Ru, Tucker, George, Bulik-Sullivan, Brendan K, Vilhjálmsson, Bjarni J, Finucane, Hilary K, Salem, Rany M, Chasman, Daniel I, Ridker, Paul M, Neale, Benjamin M, Berger, Bonnie, Patterson, Nick, Price, Alkes L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342297/ https://www.ncbi.nlm.nih.gov/pubmed/25642633 http://dx.doi.org/10.1038/ng.3190

Ejemplares similares

An Atlas of Genetic Correlations across Human Diseases and Traits
por: Bulik-Sullivan, Brendan, et al.
Publicado: (2015)

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance components analysis
por: Loh, Po-Ru, et al.
Publicado: (2015)

Functional architecture of low-frequency variants highlights strength of negative selection across coding and noncoding annotations
por: Gazal, Steven, et al.
Publicado: (2018)

Partitioning heritability by functional annotation using genome-wide association summary statistics
por: Finucane, Hilary K., et al.
Publicado: (2015)

Incorporating family history of disease improves polygenic risk scores in diverse populations
por: Hujoel, Margaux L.A., et al.
Publicado: (2022)

Improving the Power of GWAS and Avoiding Confounding from Population Stratification with PC-Select
por: Tucker, George, et al.
Publicado: (2014)

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
por: Schoech, Armin P., et al.
Publicado: (2019)

Liability threshold modeling of case-control status and family history of disease increases association power
por: Hujoel, Margaux L.A., et al.
Publicado: (2020)

Phenotype Prediction Using Regularized Regression on Genetic Data in the DREAM5 Systems Genetics B Challenge
por: Loh, Po-Ru, et al.
Publicado: (2011)

A sampling framework for incorporating quantitative mass spectrometry data in protein interaction analysis
por: Tucker, George, et al.
Publicado: (2013)

Fast and accurate long-range phasing in a UK Biobank cohort
por: Loh, Po-Ru, et al.
Publicado: (2016)

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
por: Zheng, Jie, et al.
Publicado: (2017)

Reference-based phasing using the Haplotype Reference Consortium panel
por: Loh, Po-Ru, et al.
Publicado: (2016)

Insights about clonal hematopoiesis from 8,342 mosaic chromosomal alterations
por: Loh, Po-Ru, et al.
Publicado: (2018)

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations
por: Luo, Yang, et al.
Publicado: (2021)

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
por: Hormozdiari, Farhad, et al.
Publicado: (2018)

Shared genetic aetiology of puberty timing between sexes and with health-related outcomes
por: Day, Felix R., et al.
Publicado: (2015)

Quantifying Missing Heritability at Known GWAS Loci
por: Gusev, Alexander, et al.
Publicado: (2013)

Headaches and polygenic scores
por: Vilhjálmsson, Bjarni J., et al.
Publicado: (2019)

Efficient Moment-Based Inference of Admixture Parameters and Sources of Gene Flow
por: Lipson, Mark, et al.
Publicado: (2013)

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes
por: Lipson, Mark, et al.
Publicado: (2015)

Inferring Admixture Histories of Human Populations Using Linkage Disequilibrium
por: Loh, Po-Ru, et al.
Publicado: (2013)

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
por: Finucane, Hilary K., et al.
Publicado: (2018)

Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets
por: Márquez-Luna, Carla, et al.
Publicado: (2021)

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
por: Reshef, Yakir A, et al.
Publicado: (2018)

LDpred2: better, faster, stronger
por: Privé, Florian, et al.
Publicado: (2020)

Improved genetic prediction of complex traits from individual-level data or summary statistics
por: Zhang, Qianqian, et al.
Publicado: (2021)

Linking the association between circRNAs and Alzheimer’s disease progression by multi-tissue circular RNA characterization
por: Lo, IJu, et al.
Publicado: (2020)

Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores
por: Privé, Florian, et al.
Publicado: (2022)

Reconstructing Austronesian population history in Island Southeast Asia
por: Lipson, Mark, et al.
Publicado: (2014)

Population Structure and Eigenanalysis
por: Patterson, Nick, et al.
Publicado: (2006)

Novel genetic markers improve measures of atrial fibrillation risk prediction
por: Everett, Brendan M., et al.
Publicado: (2013)

Assessing statistical significance in causal graphs
por: Chindelevitch, Leonid, et al.
Publicado: (2012)

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
por: Gusev, Alexander, et al.
Publicado: (2018)

Leveraging fine-mapping and multi-population training data to improve cross-population polygenic risk scores
por: Weissbrod, Omer, et al.
Publicado: (2022)

Anorexia nervosa and inflammatory bowel diseases—Diagnostic and genetic associations
por: Larsen, Janne Tidselbak, et al.
Publicado: (2021)

Estimating and interpreting F(ST): The impact of rare variants
por: Bhatia, Gaurav, et al.
Publicado: (2013)

On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study
por: Paré, Guillaume, et al.
Publicado: (2010)

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction
por: Albiñana, Clara, et al.
Publicado: (2021)

Prioritization of Genetic Variants in the microRNA Regulome as Functional Candidates in Genome-Wide Association Studies
por: Bulik-Sullivan, Brendan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_cen0nc4so8pnqf03ub9v9hs6ch