Low SAMHD1 expression following T-cell activation and proliferation renders CD4(+) T cells susceptible to HIV-1

OBJECTIVES: HIV-1 replication depends on the state of cell activation and division. It is established that SAMHD1 restricts HIV-1 infection of resting CD4(+) T cells. The modulation of SAMHD1 expression during T-cell activation and proliferation, however, remains unclear, as well as a role for SAMHD...

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Detalles Bibliográficos
Autores principales: Ruffin, Nicolas, Brezar, Vedran, Ayinde, Diana, Lefebvre, Cécile, Wiesch, Julian Schulze Zur, van Lunzen, Jan, Bockhorn, Maximilian, Schwartz, Olivier, Hocini, Hakim, Lelievre, Jean-Daniel, Banchereau, Jacques, Levy, Yves, Seddiki, Nabila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342413/
https://www.ncbi.nlm.nih.gov/pubmed/25715102
http://dx.doi.org/10.1097/QAD.0000000000000594

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