A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity

The steadily rising frequency of emerging diseases and antibiotic resistance creates an urgent need for new drugs and targets. Inosine 5′-monophosphate dehydrogenase (IMP dehydrogenase or IMPDH) is a promising target for the development of new antimicrobial agents. IMPDH catalyzes the oxidation of I...

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Detalles Bibliográficos
Autores principales: Makowska-Grzyska, Magdalena, Kim, Youngchang, Maltseva, Natalia, Osipiuk, Jerzy, Gu, Minyi, Zhang, Minjia, Mandapati, Kavitha, Gollapalli, Deviprasad R., Gorla, Suresh Kumar, Hedstrom, Lizbeth, Joachimiak, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342496/
https://www.ncbi.nlm.nih.gov/pubmed/25572472
http://dx.doi.org/10.1074/jbc.M114.619767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342496/
https://www.ncbi.nlm.nih.gov/pubmed/25572472
http://dx.doi.org/10.1074/jbc.M114.619767

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