Number of sons contributes to ageing-associated inflammation

The rate of inflammation increases in elderly individuals, a phenomenon called inflammaging, and is associated with degenerative diseases. However, the causes of inflammaging and the origin of the associated inflammatory mediators have remained enigmatic. We show herein that there is a positive corr...

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Detalles Bibliográficos
Autores principales: Marttila, Saara, Nevalainen, Tapio, Kananen, Laura, Jylhävä, Juulia, Jylhä, Marja, Hervonen, Antti, Ilonen, Jorma, Hurme, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342565/
https://www.ncbi.nlm.nih.gov/pubmed/25721217
http://dx.doi.org/10.1038/srep08631
Descripción
Sumario:The rate of inflammation increases in elderly individuals, a phenomenon called inflammaging, and is associated with degenerative diseases. However, the causes of inflammaging and the origin of the associated inflammatory mediators have remained enigmatic. We show herein that there is a positive correlation between the number of sons born and C-reactive protein concentrations in 90-year-old women. This association is influenced by HLA genetics known to regulate the immune response against HY antigens.

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