Cargando…
Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis
BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis. METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342681/ https://www.ncbi.nlm.nih.gov/pubmed/24789741 http://dx.doi.org/10.1093/trstmh/tru065 |
_version_ | 1782359305909960704 |
---|---|
author | Sternberg, Jeremy M. Mitchell, Julia A. |
author_facet | Sternberg, Jeremy M. Mitchell, Julia A. |
author_sort | Sternberg, Jeremy M. |
collection | PubMed |
description | BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis. METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data. RESULTS: Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages. CONCLUSION: Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation. |
format | Online Article Text |
id | pubmed-4342681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43426812015-03-17 Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis Sternberg, Jeremy M. Mitchell, Julia A. Trans R Soc Trop Med Hyg Short Communication BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis. METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data. RESULTS: Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages. CONCLUSION: Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation. Oxford University Press 2014-07 2014-04-30 /pmc/articles/PMC4342681/ /pubmed/24789741 http://dx.doi.org/10.1093/trstmh/tru065 Text en © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Sternberg, Jeremy M. Mitchell, Julia A. Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis |
title | Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis |
title_full | Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis |
title_fullStr | Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis |
title_full_unstemmed | Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis |
title_short | Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis |
title_sort | plasma neuronal specific enolase: a potential stage diagnostic marker in human african trypanosomiasis |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342681/ https://www.ncbi.nlm.nih.gov/pubmed/24789741 http://dx.doi.org/10.1093/trstmh/tru065 |
work_keys_str_mv | AT sternbergjeremym plasmaneuronalspecificenolaseapotentialstagediagnosticmarkerinhumanafricantrypanosomiasis AT mitchelljuliaa plasmaneuronalspecificenolaseapotentialstagediagnosticmarkerinhumanafricantrypanosomiasis |