Telomerase expression in the glial scar of rats with spinal cord injury★

A rat model of spinal cord injury was established using the weight drop method. A cavity formed 14 days following spinal cord injury, and compact scar tissue formed by 56 days. Enzyme-linked immunosorbent assay and polymerase chain reaction enzyme-linked immunosorbent assay results demonstrated that...

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Autores principales: Yang, Mingkun, Sheng, Weibin, Xu, Tao, Huang, Kai, Wang, Yanjiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Spinal Cord Injury and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342706/
https://www.ncbi.nlm.nih.gov/pubmed/25737706
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.002
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author Yang, Mingkun
Sheng, Weibin
Xu, Tao
Huang, Kai
Wang, Yanjiao
author_facet Yang, Mingkun
Sheng, Weibin
Xu, Tao
Huang, Kai
Wang, Yanjiao
author_sort Yang, Mingkun
collection PubMed
description A rat model of spinal cord injury was established using the weight drop method. A cavity formed 14 days following spinal cord injury, and compact scar tissue formed by 56 days. Enzyme-linked immunosorbent assay and polymerase chain reaction enzyme-linked immunosorbent assay results demonstrated that glial fibrillary acidic protein and telomerase expression increased gradually after injury, peaked at 28 days, and then gradually decreased. Spearman rank correlation showed a positive correlation between glial fibrillary acidic protein expression and telomerase expression in the glial scar. These results suggest that telomerase promotes glial scar formation.
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spelling pubmed-43427062015-03-03 Telomerase expression in the glial scar of rats with spinal cord injury★ Yang, Mingkun Sheng, Weibin Xu, Tao Huang, Kai Wang, Yanjiao Neural Regen Res Research and Report: Spinal Cord Injury and Neuroregeneration A rat model of spinal cord injury was established using the weight drop method. A cavity formed 14 days following spinal cord injury, and compact scar tissue formed by 56 days. Enzyme-linked immunosorbent assay and polymerase chain reaction enzyme-linked immunosorbent assay results demonstrated that glial fibrillary acidic protein and telomerase expression increased gradually after injury, peaked at 28 days, and then gradually decreased. Spearman rank correlation showed a positive correlation between glial fibrillary acidic protein expression and telomerase expression in the glial scar. These results suggest that telomerase promotes glial scar formation. Medknow Publications & Media Pvt Ltd 2012-04-15 /pmc/articles/PMC4342706/ /pubmed/25737706 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Spinal Cord Injury and Neuroregeneration
Yang, Mingkun
Sheng, Weibin
Xu, Tao
Huang, Kai
Wang, Yanjiao
Telomerase expression in the glial scar of rats with spinal cord injury★
title Telomerase expression in the glial scar of rats with spinal cord injury★
title_full Telomerase expression in the glial scar of rats with spinal cord injury★
title_fullStr Telomerase expression in the glial scar of rats with spinal cord injury★
title_full_unstemmed Telomerase expression in the glial scar of rats with spinal cord injury★
title_short Telomerase expression in the glial scar of rats with spinal cord injury★
title_sort telomerase expression in the glial scar of rats with spinal cord injury★
topic Research and Report: Spinal Cord Injury and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342706/
https://www.ncbi.nlm.nih.gov/pubmed/25737706
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.002
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