A non-opioid pathway for dynorphin-caused spinal cord injury in rats☆

Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the p...

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Detalles Bibliográficos
Autores principales: Chen, Yu, Xiang, Liangbi, Liu, Jun, Zhou, Dapeng, Yu, Hailong, Wang, Qi, Han, Wenfeng, Guo, Mingming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Spinal Cord Injury and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342707/
https://www.ncbi.nlm.nih.gov/pubmed/25737707
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.003
Descripción
Sumario:Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.

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