Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★

A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediat...

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Detalles Bibliográficos
Autores principales: Xiao, Feng, Xiong, Liangzhi, Wang, Qingxiu, Zhou, Long, Zhou, Qingshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Technique and Methods: Brain Injury and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342710/
https://www.ncbi.nlm.nih.gov/pubmed/25737710
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.006
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author Xiao, Feng
Xiong, Liangzhi
Wang, Qingxiu
Zhou, Long
Zhou, Qingshan
author_facet Xiao, Feng
Xiong, Liangzhi
Wang, Qingxiu
Zhou, Long
Zhou, Qingshan
author_sort Xiao, Feng
collection PubMed
description A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ischemia/reperfusion significantly decreased infarct volume. Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus, but nuclear factor kappa B expression was unaltered. In addition, the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion. These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.
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spelling pubmed-43427102015-03-03 Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★ Xiao, Feng Xiong, Liangzhi Wang, Qingxiu Zhou, Long Zhou, Qingshan Neural Regen Res Technique and Methods: Brain Injury and Neuroregeneration A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ischemia/reperfusion significantly decreased infarct volume. Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus, but nuclear factor kappa B expression was unaltered. In addition, the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion. These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus. Medknow Publications & Media Pvt Ltd 2012-04-15 /pmc/articles/PMC4342710/ /pubmed/25737710 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.006 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technique and Methods: Brain Injury and Neuroregeneration
Xiao, Feng
Xiong, Liangzhi
Wang, Qingxiu
Zhou, Long
Zhou, Qingshan
Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★
title Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★
title_full Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★
title_fullStr Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★
title_full_unstemmed Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★
title_short Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★
title_sort ketamine inhibits c-jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury★
topic Technique and Methods: Brain Injury and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342710/
https://www.ncbi.nlm.nih.gov/pubmed/25737710
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.006
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