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Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆
The present study established a rabbit model of global cerebral ischemia using the ‘six-vessel’ method, which was reperfused after 30 minutes of ischemia. Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342711/ https://www.ncbi.nlm.nih.gov/pubmed/25737711 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.007 |
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author | Wei, Xiaodong Wan, Xing Zhao, Bo Hou, Jiabao Liu, Min Cheng, Bangchang |
author_facet | Wei, Xiaodong Wan, Xing Zhao, Bo Hou, Jiabao Liu, Min Cheng, Bangchang |
author_sort | Wei, Xiaodong |
collection | PubMed |
description | The present study established a rabbit model of global cerebral ischemia using the ‘six-vessel’ method, which was reperfused after 30 minutes of ischemia. Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared. Results revealed that propofol inhibited serum interleukin-8, endothelin-1 and malondialdehyde increases and promoted plasma superoxide dismutase activity after cerebral ischemia/reperfusion. In addition, cerebral cortex edema was attenuated with little neuronal nuclear degeneration and pyknosis with propofol treatment. The cross-sectional area of neuronal nuclei was, however, increased following propofol treatment. These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury. |
format | Online Article Text |
id | pubmed-4342711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43427112015-03-03 Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ Wei, Xiaodong Wan, Xing Zhao, Bo Hou, Jiabao Liu, Min Cheng, Bangchang Neural Regen Res Technique and Methods: Brain Injury and Neuroregeneration The present study established a rabbit model of global cerebral ischemia using the ‘six-vessel’ method, which was reperfused after 30 minutes of ischemia. Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared. Results revealed that propofol inhibited serum interleukin-8, endothelin-1 and malondialdehyde increases and promoted plasma superoxide dismutase activity after cerebral ischemia/reperfusion. In addition, cerebral cortex edema was attenuated with little neuronal nuclear degeneration and pyknosis with propofol treatment. The cross-sectional area of neuronal nuclei was, however, increased following propofol treatment. These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury. Medknow Publications & Media Pvt Ltd 2012-04-15 /pmc/articles/PMC4342711/ /pubmed/25737711 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.007 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Technique and Methods: Brain Injury and Neuroregeneration Wei, Xiaodong Wan, Xing Zhao, Bo Hou, Jiabao Liu, Min Cheng, Bangchang Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ |
title | Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ |
title_full | Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ |
title_fullStr | Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ |
title_full_unstemmed | Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ |
title_short | Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ |
title_sort | propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ |
topic | Technique and Methods: Brain Injury and Neuroregeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342711/ https://www.ncbi.nlm.nih.gov/pubmed/25737711 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.007 |
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