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Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆

The present study established a rabbit model of global cerebral ischemia using the ‘six-vessel’ method, which was reperfused after 30 minutes of ischemia. Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared....

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Autores principales: Wei, Xiaodong, Wan, Xing, Zhao, Bo, Hou, Jiabao, Liu, Min, Cheng, Bangchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342711/
https://www.ncbi.nlm.nih.gov/pubmed/25737711
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.007
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author Wei, Xiaodong
Wan, Xing
Zhao, Bo
Hou, Jiabao
Liu, Min
Cheng, Bangchang
author_facet Wei, Xiaodong
Wan, Xing
Zhao, Bo
Hou, Jiabao
Liu, Min
Cheng, Bangchang
author_sort Wei, Xiaodong
collection PubMed
description The present study established a rabbit model of global cerebral ischemia using the ‘six-vessel’ method, which was reperfused after 30 minutes of ischemia. Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared. Results revealed that propofol inhibited serum interleukin-8, endothelin-1 and malondialdehyde increases and promoted plasma superoxide dismutase activity after cerebral ischemia/reperfusion. In addition, cerebral cortex edema was attenuated with little neuronal nuclear degeneration and pyknosis with propofol treatment. The cross-sectional area of neuronal nuclei was, however, increased following propofol treatment. These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury.
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spelling pubmed-43427112015-03-03 Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆ Wei, Xiaodong Wan, Xing Zhao, Bo Hou, Jiabao Liu, Min Cheng, Bangchang Neural Regen Res Technique and Methods: Brain Injury and Neuroregeneration The present study established a rabbit model of global cerebral ischemia using the ‘six-vessel’ method, which was reperfused after 30 minutes of ischemia. Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared. Results revealed that propofol inhibited serum interleukin-8, endothelin-1 and malondialdehyde increases and promoted plasma superoxide dismutase activity after cerebral ischemia/reperfusion. In addition, cerebral cortex edema was attenuated with little neuronal nuclear degeneration and pyknosis with propofol treatment. The cross-sectional area of neuronal nuclei was, however, increased following propofol treatment. These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury. Medknow Publications & Media Pvt Ltd 2012-04-15 /pmc/articles/PMC4342711/ /pubmed/25737711 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.007 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technique and Methods: Brain Injury and Neuroregeneration
Wei, Xiaodong
Wan, Xing
Zhao, Bo
Hou, Jiabao
Liu, Min
Cheng, Bangchang
Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆
title Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆
title_full Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆
title_fullStr Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆
title_full_unstemmed Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆
title_short Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆
title_sort propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits☆
topic Technique and Methods: Brain Injury and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342711/
https://www.ncbi.nlm.nih.gov/pubmed/25737711
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.007
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