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Prediction of Pharmacokinetics and Penetration of Moxifloxacin in Human with Intra-Abdominal Infection Based on Extrapolated PBPK Model

The aim of this study is to develop a physiologically based pharmacokinetic (PBPK) model in intra-abdominal infected rats, and extrapolate it to human to predict moxifloxacin pharmacokinetics profiles in various tissues in intra-abdominal infected human. 12 male rats with intra-abdominal infections,...

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Detalles Bibliográficos
Autores principales:	Zhu, LiQin, Yang, JianWei, Zhang, Yuan, Wang, YongMing, Zhang, JianLei, Zhao, YuanYuan, Dong, WeiLin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Physiological Society and The Korean Society of Pharmacology 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342742/ https://www.ncbi.nlm.nih.gov/pubmed/25729270 http://dx.doi.org/10.4196/kjpp.2015.19.2.99

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