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Characterization of the differences in the cyclopiazonic acid binding mode to mammalian and P. Falciparum Ca(2+) pumps: A computational study

Despite the investments in malaria research, an effective vaccine has not yet been developed and the causative parasites are becoming increasingly resistant to most of the available drugs. PfATP6, the sarco/endoplasmic reticulum Ca2+ pump (SERCA) of P. falciparum, has been recently genetically valid...

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Detalles Bibliográficos
Autores principales: Di Marino, Daniele, D'Annessa, Ilda, Coletta, Andrea, Via, Allegra, Tramontano, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342768/
https://www.ncbi.nlm.nih.gov/pubmed/25581715
http://dx.doi.org/10.1002/prot.24734