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Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity

BACKGROUND: Distinct, partly competing, “waves” have been proposed to explain human migration in(to) today’s Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in...

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Autores principales: Gomes, Sibylle M, Bodner, Martin, Souto, Luis, Zimmermann, Bettina, Huber, Gabriela, Strobl, Christina, Röck, Alexander W, Achilli, Alessandro, Olivieri, Anna, Torroni, Antonio, Côrte-Real, Francisco, Parson, Walther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342813/
https://www.ncbi.nlm.nih.gov/pubmed/25757516
http://dx.doi.org/10.1186/s12864-014-1201-x
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author Gomes, Sibylle M
Bodner, Martin
Souto, Luis
Zimmermann, Bettina
Huber, Gabriela
Strobl, Christina
Röck, Alexander W
Achilli, Alessandro
Olivieri, Anna
Torroni, Antonio
Côrte-Real, Francisco
Parson, Walther
author_facet Gomes, Sibylle M
Bodner, Martin
Souto, Luis
Zimmermann, Bettina
Huber, Gabriela
Strobl, Christina
Röck, Alexander W
Achilli, Alessandro
Olivieri, Anna
Torroni, Antonio
Côrte-Real, Francisco
Parson, Walther
author_sort Gomes, Sibylle M
collection PubMed
description BACKGROUND: Distinct, partly competing, “waves” have been proposed to explain human migration in(to) today’s Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in a forensic environment, we used the Ion Torrent Personal Genome Machine (PGM) for generating complete mitogenome sequences via stand-alone massively parallel sequencing and describe a standard data validation practice. RESULTS: In this first representative investigation on the mitochondrial DNA (mtDNA) variation of East Timor (Timor-Leste) population including >300 individuals, we put special emphasis on the reconstruction of the initial settlement, in particular on the previously poorly resolved haplogroup P1, an indigenous lineage of the Southwest Pacific region. Our results suggest a colonization of southern Sahul (Australia) >37 kya, limited subsequent exchange, and a parallel incubation of initial settlers in northern Sahul (New Guinea) followed by westward migrations <28 kya. CONCLUSIONS: The temporal proximity and possible coincidence of these latter dispersals, which encompassed autochthonous haplogroups, with the postulated “later” events of (South) East Asian origin pinpoints a highly dynamic migratory phase. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-014-1201-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-43428132015-02-28 Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity Gomes, Sibylle M Bodner, Martin Souto, Luis Zimmermann, Bettina Huber, Gabriela Strobl, Christina Röck, Alexander W Achilli, Alessandro Olivieri, Anna Torroni, Antonio Côrte-Real, Francisco Parson, Walther BMC Genomics Research Article BACKGROUND: Distinct, partly competing, “waves” have been proposed to explain human migration in(to) today’s Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in a forensic environment, we used the Ion Torrent Personal Genome Machine (PGM) for generating complete mitogenome sequences via stand-alone massively parallel sequencing and describe a standard data validation practice. RESULTS: In this first representative investigation on the mitochondrial DNA (mtDNA) variation of East Timor (Timor-Leste) population including >300 individuals, we put special emphasis on the reconstruction of the initial settlement, in particular on the previously poorly resolved haplogroup P1, an indigenous lineage of the Southwest Pacific region. Our results suggest a colonization of southern Sahul (Australia) >37 kya, limited subsequent exchange, and a parallel incubation of initial settlers in northern Sahul (New Guinea) followed by westward migrations <28 kya. CONCLUSIONS: The temporal proximity and possible coincidence of these latter dispersals, which encompassed autochthonous haplogroups, with the postulated “later” events of (South) East Asian origin pinpoints a highly dynamic migratory phase. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-014-1201-x) contains supplementary material, which is available to authorized users. BioMed Central 2015-02-14 /pmc/articles/PMC4342813/ /pubmed/25757516 http://dx.doi.org/10.1186/s12864-014-1201-x Text en © Gomes et al.; licensee Biomed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Gomes, Sibylle M
Bodner, Martin
Souto, Luis
Zimmermann, Bettina
Huber, Gabriela
Strobl, Christina
Röck, Alexander W
Achilli, Alessandro
Olivieri, Anna
Torroni, Antonio
Côrte-Real, Francisco
Parson, Walther
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity
title Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity
title_full Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity
title_fullStr Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity
title_full_unstemmed Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity
title_short Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity
title_sort human settlement history between sunda and sahul: a focus on east timor (timor-leste) and the pleistocenic mtdna diversity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342813/
https://www.ncbi.nlm.nih.gov/pubmed/25757516
http://dx.doi.org/10.1186/s12864-014-1201-x
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