Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma

BACKGROUND: HOX genes are a family of developmental genes that are expressed neither in the developing forebrain nor in the normal brain. Aberrant expression of a HOX-gene dominated stem-cell signature in glioblastoma has been linked with increased resistance to chemo-radiotherapy and sustained prol...

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Detalles Bibliográficos
Autores principales: Kurscheid, Sebastian, Bady, Pierre, Sciuscio, Davide, Samarzija, Ivana, Shay, Tal, Vassallo, Irene, Criekinge, Wim V, Daniel, Roy T, van den Bent, Martin J, Marosi, Christine, Weller, Michael, Mason, Warren P, Domany, Eytan, Stupp, Roger, Delorenzi, Mauro, Hegi, Monika E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342872/
https://www.ncbi.nlm.nih.gov/pubmed/25622821
http://dx.doi.org/10.1186/s13059-015-0583-7

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