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Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
BACKGROUND: Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated. METHODS: Clinically stable out-patients with idiopathic pulmonary arterial h...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342878/ https://www.ncbi.nlm.nih.gov/pubmed/25888026 http://dx.doi.org/10.1186/s12890-015-0005-3 |
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author | Tiede, Henning Rorzyczka, Janet Dumitrascu, Rio Belly, Michael Reichenberger, Frank Ghofrani, Hossein Ardeschir Seeger, Werner Heitmann, Jörg Schulz, Richard |
author_facet | Tiede, Henning Rorzyczka, Janet Dumitrascu, Rio Belly, Michael Reichenberger, Frank Ghofrani, Hossein Ardeschir Seeger, Werner Heitmann, Jörg Schulz, Richard |
author_sort | Tiede, Henning |
collection | PubMed |
description | BACKGROUND: Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated. METHODS: Clinically stable out-patients with idiopathic pulmonary arterial hypertension (IPAH, n = 52) and chronic thromboembolic PH (CTEPH, n = 64) in NYHA classes II and III were prospectively enrolled. 54 healthy volunteers matched for anthropometric variables served as a control group. The Pittsburgh Sleep Quality Index (PSQI) was used to rate subjective sleep quality. In the PH patients, six-minute walk tests (6MWT) were performed to assess exercise capacity. RESULTS: Poor sleep quality (i.e. a PSQI score > 5) occurred more frequently in PH (IPAH: n = 25 [48.1%], CTEPH: n = 39 [60.9%], controls: n = 10 [18.5%]; p < 0.01 when compared to controls). In addition, poor vs. good sleepers had significantly higher average NYHA class (IPAH: 2.6 ± 0.1 vs. 2.3 ± 0.1, CTEPH: 2.8 ± 0.1 vs. 2.3 ± 0.2; p < 0.01) and shorter 6MWT distances (IPAH: 338 ± 23 vs. 441 ± 29 m, CTEPH: 355 ± 15 vs. 413 ± 26 m; p < 0.05). CONCLUSIONS: Self-reported poor sleep quality is more common in PH than in healthy controls. Furthermore, it is related to reduced physical exercise capacity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0005-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4342878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43428782015-02-28 Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension Tiede, Henning Rorzyczka, Janet Dumitrascu, Rio Belly, Michael Reichenberger, Frank Ghofrani, Hossein Ardeschir Seeger, Werner Heitmann, Jörg Schulz, Richard BMC Pulm Med Research Article BACKGROUND: Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated. METHODS: Clinically stable out-patients with idiopathic pulmonary arterial hypertension (IPAH, n = 52) and chronic thromboembolic PH (CTEPH, n = 64) in NYHA classes II and III were prospectively enrolled. 54 healthy volunteers matched for anthropometric variables served as a control group. The Pittsburgh Sleep Quality Index (PSQI) was used to rate subjective sleep quality. In the PH patients, six-minute walk tests (6MWT) were performed to assess exercise capacity. RESULTS: Poor sleep quality (i.e. a PSQI score > 5) occurred more frequently in PH (IPAH: n = 25 [48.1%], CTEPH: n = 39 [60.9%], controls: n = 10 [18.5%]; p < 0.01 when compared to controls). In addition, poor vs. good sleepers had significantly higher average NYHA class (IPAH: 2.6 ± 0.1 vs. 2.3 ± 0.1, CTEPH: 2.8 ± 0.1 vs. 2.3 ± 0.2; p < 0.01) and shorter 6MWT distances (IPAH: 338 ± 23 vs. 441 ± 29 m, CTEPH: 355 ± 15 vs. 413 ± 26 m; p < 0.05). CONCLUSIONS: Self-reported poor sleep quality is more common in PH than in healthy controls. Furthermore, it is related to reduced physical exercise capacity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0005-3) contains supplementary material, which is available to authorized users. BioMed Central 2015-02-13 /pmc/articles/PMC4342878/ /pubmed/25888026 http://dx.doi.org/10.1186/s12890-015-0005-3 Text en © Tiede et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Tiede, Henning Rorzyczka, Janet Dumitrascu, Rio Belly, Michael Reichenberger, Frank Ghofrani, Hossein Ardeschir Seeger, Werner Heitmann, Jörg Schulz, Richard Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension |
title | Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension |
title_full | Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension |
title_fullStr | Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension |
title_full_unstemmed | Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension |
title_short | Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension |
title_sort | poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342878/ https://www.ncbi.nlm.nih.gov/pubmed/25888026 http://dx.doi.org/10.1186/s12890-015-0005-3 |
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