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Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension

BACKGROUND: Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated. METHODS: Clinically stable out-patients with idiopathic pulmonary arterial h...

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Autores principales: Tiede, Henning, Rorzyczka, Janet, Dumitrascu, Rio, Belly, Michael, Reichenberger, Frank, Ghofrani, Hossein Ardeschir, Seeger, Werner, Heitmann, Jörg, Schulz, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342878/
https://www.ncbi.nlm.nih.gov/pubmed/25888026
http://dx.doi.org/10.1186/s12890-015-0005-3
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author Tiede, Henning
Rorzyczka, Janet
Dumitrascu, Rio
Belly, Michael
Reichenberger, Frank
Ghofrani, Hossein Ardeschir
Seeger, Werner
Heitmann, Jörg
Schulz, Richard
author_facet Tiede, Henning
Rorzyczka, Janet
Dumitrascu, Rio
Belly, Michael
Reichenberger, Frank
Ghofrani, Hossein Ardeschir
Seeger, Werner
Heitmann, Jörg
Schulz, Richard
author_sort Tiede, Henning
collection PubMed
description BACKGROUND: Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated. METHODS: Clinically stable out-patients with idiopathic pulmonary arterial hypertension (IPAH, n = 52) and chronic thromboembolic PH (CTEPH, n = 64) in NYHA classes II and III were prospectively enrolled. 54 healthy volunteers matched for anthropometric variables served as a control group. The Pittsburgh Sleep Quality Index (PSQI) was used to rate subjective sleep quality. In the PH patients, six-minute walk tests (6MWT) were performed to assess exercise capacity. RESULTS: Poor sleep quality (i.e. a PSQI score > 5) occurred more frequently in PH (IPAH: n = 25 [48.1%], CTEPH: n = 39 [60.9%], controls: n = 10 [18.5%]; p < 0.01 when compared to controls). In addition, poor vs. good sleepers had significantly higher average NYHA class (IPAH: 2.6 ± 0.1 vs. 2.3 ± 0.1, CTEPH: 2.8 ± 0.1 vs. 2.3 ± 0.2; p < 0.01) and shorter 6MWT distances (IPAH: 338 ± 23 vs. 441 ± 29 m, CTEPH: 355 ± 15 vs. 413 ± 26 m; p < 0.05). CONCLUSIONS: Self-reported poor sleep quality is more common in PH than in healthy controls. Furthermore, it is related to reduced physical exercise capacity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0005-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-43428782015-02-28 Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension Tiede, Henning Rorzyczka, Janet Dumitrascu, Rio Belly, Michael Reichenberger, Frank Ghofrani, Hossein Ardeschir Seeger, Werner Heitmann, Jörg Schulz, Richard BMC Pulm Med Research Article BACKGROUND: Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated. METHODS: Clinically stable out-patients with idiopathic pulmonary arterial hypertension (IPAH, n = 52) and chronic thromboembolic PH (CTEPH, n = 64) in NYHA classes II and III were prospectively enrolled. 54 healthy volunteers matched for anthropometric variables served as a control group. The Pittsburgh Sleep Quality Index (PSQI) was used to rate subjective sleep quality. In the PH patients, six-minute walk tests (6MWT) were performed to assess exercise capacity. RESULTS: Poor sleep quality (i.e. a PSQI score > 5) occurred more frequently in PH (IPAH: n = 25 [48.1%], CTEPH: n = 39 [60.9%], controls: n = 10 [18.5%]; p < 0.01 when compared to controls). In addition, poor vs. good sleepers had significantly higher average NYHA class (IPAH: 2.6 ± 0.1 vs. 2.3 ± 0.1, CTEPH: 2.8 ± 0.1 vs. 2.3 ± 0.2; p < 0.01) and shorter 6MWT distances (IPAH: 338 ± 23 vs. 441 ± 29 m, CTEPH: 355 ± 15 vs. 413 ± 26 m; p < 0.05). CONCLUSIONS: Self-reported poor sleep quality is more common in PH than in healthy controls. Furthermore, it is related to reduced physical exercise capacity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0005-3) contains supplementary material, which is available to authorized users. BioMed Central 2015-02-13 /pmc/articles/PMC4342878/ /pubmed/25888026 http://dx.doi.org/10.1186/s12890-015-0005-3 Text en © Tiede et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Tiede, Henning
Rorzyczka, Janet
Dumitrascu, Rio
Belly, Michael
Reichenberger, Frank
Ghofrani, Hossein Ardeschir
Seeger, Werner
Heitmann, Jörg
Schulz, Richard
Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
title Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
title_full Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
title_fullStr Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
title_full_unstemmed Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
title_short Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
title_sort poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342878/
https://www.ncbi.nlm.nih.gov/pubmed/25888026
http://dx.doi.org/10.1186/s12890-015-0005-3
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