One-Pot, Three-Component Arylalkynyl Sulfone Synthesis

[Image: see text] A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO·SO(2)), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported. A broad range of aryl and he...

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Detalles Bibliográficos
Autores principales: Chen, C. Chun, Waser, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342956/
https://www.ncbi.nlm.nih.gov/pubmed/25633719
http://dx.doi.org/10.1021/acs.orglett.5b00015
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author Chen, C. Chun
Waser, Jerome
author_facet Chen, C. Chun
Waser, Jerome
author_sort Chen, C. Chun
collection PubMed
description [Image: see text] A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO·SO(2)), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported. A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46–85% overall yield.
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spelling pubmed-43429562015-03-02 One-Pot, Three-Component Arylalkynyl Sulfone Synthesis Chen, C. Chun Waser, Jerome Org Lett [Image: see text] A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO·SO(2)), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported. A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46–85% overall yield. American Chemical Society 2015-01-29 2015-02-06 /pmc/articles/PMC4342956/ /pubmed/25633719 http://dx.doi.org/10.1021/acs.orglett.5b00015 Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Chen, C. Chun
Waser, Jerome
One-Pot, Three-Component Arylalkynyl Sulfone Synthesis
title One-Pot, Three-Component Arylalkynyl Sulfone Synthesis
title_full One-Pot, Three-Component Arylalkynyl Sulfone Synthesis
title_fullStr One-Pot, Three-Component Arylalkynyl Sulfone Synthesis
title_full_unstemmed One-Pot, Three-Component Arylalkynyl Sulfone Synthesis
title_short One-Pot, Three-Component Arylalkynyl Sulfone Synthesis
title_sort one-pot, three-component arylalkynyl sulfone synthesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342956/
https://www.ncbi.nlm.nih.gov/pubmed/25633719
http://dx.doi.org/10.1021/acs.orglett.5b00015
work_keys_str_mv AT chencchun onepotthreecomponentarylalkynylsulfonesynthesis
AT waserjerome onepotthreecomponentarylalkynylsulfonesynthesis

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