Cargando…

Notch1 phenotype and clinical stage progression in non-small cell lung cancer

BACKGROUND: Notch1 transmembrane receptor is activated through ligand-binding- triggered proteolytic cleavages and, upon release, the intracellular domain (N1-ICD) translocates into the nucleus and modulates target gene transcriptions. Notch activation has been implicated in tumorigenesis in an incr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Dat, Rubinstein, Larry, Takebe, Naoko, Miele, Lucio, Tomaszewski, Joseph E, Ivy, Percy, Doroshow, James H, Yang, Sherry X
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343190/ https://www.ncbi.nlm.nih.gov/pubmed/25653136 http://dx.doi.org/10.1186/s13045-014-0104-2

Ejemplares similares

TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models
por: Yang, Sherry X., et al.
Publicado: (2021)

Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial-to-mesenchymal transition
por: Takebe, Naoko, et al.
Publicado: (2011)

Notch Signaling in Neuroendocrine Tumors
por: Crabtree, Judy S., et al.
Publicado: (2016)

Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells
por: Ji, Jiuping, et al.
Publicado: (2011)

DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors
por: Laranjeira, Angelo B. A., et al.
Publicado: (2023)

Notch signaling in pediatric soft tissue sarcomas
por: Rota, Rossella, et al.
Publicado: (2012)

NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications
por: Clementz, Anthony G, et al.
Publicado: (2011)

Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling
por: Hicks, Chindo, et al.
Publicado: (2011)

Triapine Radiochemotherapy in Advanced Stage Cervical Cancer
por: Kunos, Charles A., et al.
Publicado: (2018)

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
por: Espinoza, Ingrid, et al.
Publicado: (2013)

Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis
por: Hong, Weilong, et al.
Publicado: (2019)

Randomized Phase II Trial of Sunitinib or Cediranib in Alveolar Soft Part Sarcoma
por: Nguyen, James, et al.
Publicado: (2023)

Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy
por: Gu, Jian-Wei, et al.
Publicado: (2012)

Notch1 modulates timing of G(1)-S progression by inducing SKP2 transcription and p27(Kip1) degradation
por: Sarmento, Leonor M., et al.
Publicado: (2005)

Association of γH2AX at Diagnosis with Chemotherapy Outcome in Patients with Breast Cancer
por: Yang, Sherry X., et al.
Publicado: (2017)

Expanding access to early phase trials: the CATCH-UP.2020 experience
por: Baranda, Joaquina C, et al.
Publicado: (2022)

Moving Breast Cancer Therapy up a Notch
por: Mollen, Erik W. J., et al.
Publicado: (2018)

NOTCH regulation of the endothelial cell phenotype
por: Mack, Julia J., et al.
Publicado: (2018)

Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses
por: Hossain, Fokhrul, et al.
Publicado: (2018)

Association of Independent Prognostic Factors and Treatment Modality With Survival and Recurrence Outcomes in Breast Cancer
por: Nguyen, Dat, et al.
Publicado: (2020)

Potential utility of a longitudinal relative dose intensity of molecularly targeted agents in phase 1 dose‐finding trials
por: Hirakawa, Akihiro, et al.
Publicado: (2017)

Involvement of Notch Signaling in Wound Healing
por: Chigurupati, Srinivasulu, et al.
Publicado: (2007)

AKT and 14-3-3 Regulate Notch4 Nuclear Localization
por: Ramakrishnan, Gopalakrishnan, et al.
Publicado: (2015)

Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells
por: Dongre, Anushka, et al.
Publicado: (2014)

The Notch Pathway in Breast Cancer Progression
por: Kontomanolis, Emmanuel N., et al.
Publicado: (2018)

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
por: Eliasz, Sandra, et al.
Publicado: (2010)

Arsenic Trioxide Inhibits Cell Growth and Induces Apoptosis through Inactivation of Notch Signaling Pathway in Breast Cancer
por: Xia, Jun, et al.
Publicado: (2012)

Notch signalling in cancer progression and bone metastasis
por: Sethi, N, et al.
Publicado: (2011)

Vimentin and Notch as biomarkers for breast cancer progression
por: CALAF, GLORIA M., et al.
Publicado: (2014)

Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis
por: Yuan, Xun, et al.
Publicado: (2015)

Pharmacological Inhibitor of Notch Signaling Stabilizes the Progression of Small Abdominal Aortic Aneurysm in a Mouse Model
por: Cheng, Jeeyun, et al.
Publicado: (2014)

CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells
por: Mitra, Ankita, et al.
Publicado: (2020)

Advances in using PARP inhibitors to treat cancer
por: Kummar, Shivaani, et al.
Publicado: (2012)

Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells
por: Navas, Tony, et al.
Publicado: (2018)

Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands
por: Krueger, Andreas, et al.
Publicado: (2006)

Phase I Trial of Triapine–Cisplatin–Paclitaxel Chemotherapy for Advanced Stage or Metastatic Solid Tumor Cancers
por: Kunos, Charles A., et al.
Publicado: (2017)

Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia
por: Roderick, Justine E., et al.
Publicado: (2013)

Analysis of Notch and TGF-β Signaling Expression in Different Stages of Disease Progression During Hepatitis B Virus Infection
por: Trehanpati, Nirupama, et al.
Publicado: (2012)

The Efficacy of CB-103, a First-in-Class Transcriptional Notch Inhibitor, in Preclinical Models of Breast Cancer
por: Vigolo, Michele, et al.
Publicado: (2023)

Necking and notch strengthening in metallic glass with symmetric sharp-and-deep notches
por: Sha, Z. D., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_aq6pgjcanami6fr00a7vopsi0i