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Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations
Human cancers are frequently polyploid, containing multiple aneuploid subpopulations that differ in total DNA content. In this study we exploit this property to reconstruct evolutionary histories, by assuming that mutational complexity increases with time. We developed an experimental method called...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343275/ https://www.ncbi.nlm.nih.gov/pubmed/25729435 http://dx.doi.org/10.1186/s13073-015-0127-5 |